CORE--FACILITY FOR AGING RODENTS

老年啮齿动物核心设施(CFAR)为希望使用动物模型研究衰老生物学、衰老与疾病之间的关系或治疗方法的研究科学家提供动物和建议，这些方法可能有助于开发与老年人的独立性和健康护理相关的人类干预试验。CFAR由老年医学中心病理学教授兼研究副主任理查德·A·米勒博士指导。兽医咨询由实验动物医学助理教授Robert Dysko博士提供。老年和对照大鼠和小鼠从NIA合同群体购买，并提供给胡椒中心试点/可行性补助金的接受者，希望获得试点数据以准备OAIC或外部支持申请的初级教职科学家，以及希望开始研究他们尚未获得外部支持的老年学或老年学问题的知名科学家。这促进了对老年啮齿动物的接触，有助于吸引正在发展中的和成熟的科学家从事实验老年病学，并促进他们在该领域的初步尝试，同时确保他们在选择品系和物种、适当开发新的遗传异质小鼠等事项上获得(核心主任)的建议，这些小鼠是经过几代人选择性培育的，以提高细胞对动态平衡压力的抵抗力。Core将通过在每一代中选择其T淋巴细胞最耐短暂热休克或耐受体外氧化应激(过氧化氢)处理的父母来产生这些耐应激小鼠品系。以这种方式生产的小鼠品系将被UM Pepper中心的研究人员用于研究细胞动态平衡和晚年疾病的内在脆弱性之间的联系，也将被其他中心的研究人员使用。通过其项目，CFAR将继续为Pepper Center和UM的其他研究人员提供实验设计方面的咨询，促进老年大鼠和小鼠的接触，并帮助制造和鉴定新的啮齿动物模型，这些模型对衰老和老年疾病的研究特别有用。

The Core Facility for Aged Rodents (CFAR) provides animals and advice for research scientists who wish to use animal models to study the biology of aging, the relationship between aging and disease, or therapeutic approaches that could level to the development of human intervention trials relevant to the independence and health care of the elderly. CFAR is directed by Dr. Richard A. Miller, Professor of Pathology and the Associate Director for Research of the Geriatrics Center. Veterinary consultation is provided by Dr. Robert Dysko, DVM, Assistant Professor of Laboratory Animal Medicine. Aged and control rats and mice are purchased from the NIA Contract Colonies and supplied to recipients of Pepper Center Pilot/Feasibility Grants, to junior faculty scientists who wish to acquire pilot data towards the preparation of an application for OAIC or extramural support, and to established scientists who wish to begin study of a problem in geriatric or gerontology for which they do yet have external support. This facilitated access to old rodents serves to attract developing and established scientists to experimental geriatrics and to facilitate their initial forays in this filed, while at the same time ensuring that they obtain advice from the (Core Director) on matters such as choice of strain and species, appropriate development of a new stocks of genetically heterogeneous mice that have been selectively bred over several generations for improved cellular resistance to homeostatic stresses. The Core will generate these stress-resistant mouse lines by selecting parents, in each generation, whose T lymphocytes are most resistant to brief heat shock or resistant to in vitro treatment with an oxidizing stress, hydrogen peroxide. Mouse lines produced in this way will be used by UM Pepper Center investigators for studies of the connections between cellular homeostasis and intrinsic vulnerability to late life diseases, and will also be made available to researchers at other centers. Through its programs CFAR will continue to provide Pepper Center and other UM researchers with consultation on experimental design, facilitated access to aged rats and mice, and assistance in producing and characterizing new rodent models that are particularly useful for studies of aging and late life disease.