Effector export in P. falciparum infected human erythrocytes
Effector export in P. falciparum infected human erythrocytes
批准号:
nhmrc : 1121178
负责人:
A/Pr Justin Boddey
金额:
$72.85万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2017
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2017-01-01 至 2020-12-31
中文摘要
我们将调查疟疾,这是一种每年导致超过45万人死亡的寄生虫病。我们将探索这种寄生虫如何识别、入侵和重塑其所在的宿主细胞,收集营养物质并躲避免疫系统。我们将描述参与这些关键事件的蛋白质的特征,因为它们是药物的潜在靶点。我们将研究寄生虫是如何致病的,以及宿主如何对感染做出反应。
英文摘要
We will investigate malaria, a parasitic disease that kills over 450,000 people a year. We will explore how the parasite identifies, invades and remodels the host cells in which it lives, scavenging nutrients and hiding from the immune system. We will characterize the proteins involved in these critical events, as they are potential targets for drugs. We will study how parasites cause disease and how the host responds to infection.
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会议论文
Role of plasmepsin V and PTEX complex in Plasmodium liver infection
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批准号:nhmrc : GNT1139153
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项目类别:Project Grants
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资助金额:$84.84万
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财政年份:2018
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负责人:A/Pr Justin Boddey
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依托单位:
The role of protein glycosylation in the malaria parasite
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批准号:nhmrc : 1139546
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项目类别:Project Grants
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资助金额:$43.57万
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财政年份:2018
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负责人:A/Pr Justin Boddey
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依托单位:
The role of protein glycosylation in the malaria parasite
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批准号:nhmrc : GNT1139546
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项目类别:Project Grants
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资助金额:$64.44万
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财政年份:2018
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负责人:A/Pr Justin Boddey
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依托单位:
Role of plasmepsin V and PTEX complex in Plasmodium liver infection
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批准号:nhmrc : 1139153
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项目类别:Project Grants
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资助金额:$57.36万
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财政年份:2018
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负责人:A/Pr Justin Boddey
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依托单位:
Optimisation of a potent and fast acting antimalarial class that is orally efficacious in vivo
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批准号:nhmrc : GNT1135421
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项目类别:Development Grants
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资助金额:$68.39万
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财政年份:2018
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负责人:A/Pr Justin Boddey
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依托单位:
Optimisation of a potent and fast acting antimalarial class that is orally efficacious in vivo
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批准号:nhmrc : 1135421
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项目类别:Development Grants
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资助金额:$46.24万
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财政年份:2018
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负责人:A/Pr Justin Boddey
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依托单位:
Functional genomics of malaria liver infection and transmission
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批准号:nhmrc : 1123727
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项目类别:Career Development Fellowships
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资助金额:$32.12万
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财政年份:2017
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负责人:A/Pr Justin Boddey
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依托单位:
Functional genomics of malaria liver infection and transmission
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批准号:nhmrc : GNT1123727
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项目类别:Career Development Fellowships
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资助金额:$47.01万
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财政年份:2017
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负责人:A/Pr Justin Boddey
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依托单位:
Effector export in P. falciparum infected human erythrocytes
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批准号:nhmrc : GNT1121178
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项目类别:Project Grants
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资助金额:$106.69万
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财政年份:2017
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负责人:A/Pr Justin Boddey
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依托单位:
Role of exported proteins in malaria parasite development in the liver
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批准号:nhmrc : 1049811
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项目类别:Project Grants
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资助金额:$34.71万
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财政年份:2013
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负责人:A/Pr Justin Boddey
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依托单位:
Function and inhibition of Plasmepsin V in targeting malaria virulence proteins into human erythrocytes
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批准号:nhmrc : 1010326
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项目类别:Project Grants
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资助金额:$27.2万
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财政年份:2011
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负责人:A/Pr Justin Boddey
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依托单位:
Identification of the Plasmodium falciparum translocon that exports parasite proteins into their erythocytic hosts.
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批准号:nhmrc : 516740
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项目类别:NHMRC Project Grants
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资助金额:$27.27万
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财政年份:2008
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负责人:A/Pr Justin Boddey
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依托单位:
characterisation of P. Flaciparum erythrocyte-targeted proteins
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批准号:nhmrc : 461281
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项目类别:Early Career Fellowships
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资助金额:$18.8万
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财政年份:2007
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负责人:A/Pr Justin Boddey
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依托单位:
海外基金