MULTIETHNIC/MINORITY COHORT STUDY OF DIET AND CANCER

这份修订后的竞争对手续签申请是为了继续跟进 以及对一个大型流行病学队列的数据分析，该队列已经建立 1993-1996年期间在夏威夷和洛杉矶。人口-- 基于队列，由超过215,000名成员组成，其独特之处在于 多民族构成，包括大量的拉丁裔， 非裔美国人、日裔美国人和白人。入场时，每个人 参与者完成一份26页的邮寄调查问卷，其中包含 定量饮食史、医疗、用药、体力活动，以及 女性生育史；以及人口统计信息。此外 为了保持对该队列的高跟踪率，我们将研究 几种饮食因素与四种常见癌症部位的关系： 前列腺、乳腺、结直肠和肺。这些癌症之间的联系 含有营养素(例如，含有饱和脂肪的前列腺癌、番茄红素； 乳腺癌与单不饱和/饱和的比值 多不饱和脂肪，膳食纤维成分；结直肠癌 脂肪、能量、叶酸；肺癌伴特定脂肪、类胡萝卜素)和 与食物有关(例如，前列腺癌伴红肉、豆类；乳腺癌 用高纤维蔬菜；用高温烹调的肉类患结直肠癌 温度豆类；肺癌与动物产品，食物来源 类胡萝卜素)将被检测，利用两者的多样性 以及队列成员的摄入量范围。这些关系将 首先在每个民族内部进行考察。然后，一致性 将评估不同种族群体之间的关系，使用 基于24小时膳食召回数据的校正膳食暴露值 在队列中的大量子样本上收集的。最后， 饮食和非饮食数据可以解释种族间的哪些因素 癌症风险的差异将被评估。对患者的被动随访 队列将使用计算机连接到以人群为基础的癌症 在夏威夷和加利福尼亚州注册，应该至少产生2542 乳腺癌、3426例前列腺癌、2737例结直肠癌和2034例肺癌 到2002年。积极的后续行动将包括政府 在续签的头两年提交一份简短的后续问卷 期间，以及学习通讯的定期邮寄。调查结果来自 这项研究应该有助于阐明饮食与癌症的关系，以及 为了更好地了解癌症的种族差异的基础 发病率。

This revised competing renewal application is for continued follow-up and data analyses on a large epidemiologic cohort, which was established in Hawaii and Los Angeles during the period 1993-1996. The population- based cohort, comprised of more than 215,000 members is unique in its multiethnic composition, including substantial numbers of Latinos, African Americans, Japanese Americans, and whites. At entry, each participant complete a 26-page mail questionnaire that contained a quantitative diet history, medical, medication, physical activity, and female reproductive histories; and demographic information. In addition to maintaining a high rate of follow-up on the cohort, we will study the relationship of several dietary factors to four common cancer sites: prostate, breast, colorectum and lung. Associations of these cancers with nutrients (e.g., prostate cancer with saturated fat, lycopene; breast cancer with the ratio of monounsaturated to saturated/ polyunsaturated fat, components of dietary fiber; colorectal cancer with fat, energy, folate; lung cancer with specific fats, carotenoids) and with foods (e.g., prostate cancer with red meat, legumes; breast cancer with high-fiber vegetables; colorectal cancer with meats cooked at high temperature legumes; lung cancer with animal products, food sources of carotenoids) will be examined, taking advantage of both the diversity and range of intakes among cohort members. These relationships will first be examined within each ethnic group. Then, the consistency of relationships among the different ethnic group will be evaluated, using calibrated dietary exposure values based on 24-hour dietary recall data collected on a large subsample of the cohort. Finally, the extent to which dietary and non-dietary data can account for interethnic differences in cancer risk will be assessed. Passive follow-up on the cohort will use computer linkage to the population-based cancer registries in Hawaii and California, and should yield at least 2542 breast, 3426 prostate, 2737 colorectal, and 2034 lung cancer incident cases by the year 2002. Active follow-up will include the administration of a brief follow-up questionnaire in the first two years of the renewal period, as well as regular mailings of a study newsletter. Findings from this study should help to elucidate relationships of diet to cancer, and to better understand the basis for ethnic variations in cancer incidence.