Epigenetic regulation by lysine specific demethylases in breast cancer stem cells.

乳腺癌复发背后的因素尚不完全清楚，但越来越明显的是，原发性癌症的扩散可以在癌症发展的早期阶段由一小群独特的癌细胞开始，称为癌症干细胞（CSCs）。靶向这些CSCs已成为癌症治疗的一个优先领域。我们的目的是证明一类新的表观遗传酶是CSCs的关键分子靶点，并提出一种根除CSCs的策略。

The factors behind breast cancer recurrence are not fully understood but it is becoming increasingly evident that the spread of primary cancer can be initiated at a very early stage of cancer development by a small population of unique cancer cells, termed cancer stem cells (CSCs). Targeting of these CSCs has emerged as a priority area in cancer therapy. Our aim is to demonstrate that a novel class of epigenetic enzymes are key molecular targets of CSCs and propose a strategy to eradicate CSCs.