ABCA12 – a New Regulator of Cellular Lipid Metabolism and Inflammation

胆固醇代谢失调在许多疾病中起着关键作用--从糖尿病、动脉粥样硬化到神经和皮肤疾病。对胆固醇代谢的调节机制知之甚少。我们最近发现了一种调节胆固醇代谢的新途径，在这项研究中，我们将研究这一途径的分子、细胞和生理机制，并确定将其作为靶点进行治疗干预的可能性。

Dysregulation of cholesterol metabolism plays a key role in a number of diseases – from diabetes and atherosclerosis to neurological and skin disorders. Mechanisms of regulation of cholesterol metabolism are poorly understood. We have recently discovered a new pathway regulating cholesterol metabolism and in this study we will investigate molecular, cellular and physiological mechanisms of this pathway and will identify the possibilities to target it for therapeutic intervention.