Research Training in Gastroenterology

描述（由申请人提供）： 这是一个竞争性的延续申请，用于更新1999年首次资助的胃肠病学培训计划。该计划的目标是为致力于调查胃肠病学或相关领域的年轻调查人员提供研究培训。研究培训的类型包括基础，转化或临床研究，或这些的组合。受训者可能是医学博士、医学博士-博士或博士，他们已经完成了临床或研究生培训，正在寻求进一步的胃肠病学研究培训。培训期将持续两至三年。培训将主要包括指导研究，将提供大量的实践经验，研究方法和实验设计，数据收集技术，数据解释，包括适当的统计分析和研究结果的准备，以供演示和出版。还将提供一系列教学课程、讲习班、研讨会和会议。学员将由经验丰富的研究导师监督，他们具有广泛的兴趣和专业知识，从基础细胞和分子生物学到临床研究。一个由拉蒙博士、凯利博士、阿夫达尔博士和特霍斯特博士以及一两名其他培训教员组成的培训委员会将监督每个学员的研究进展。还将提供一系列教学课程、讲习班、研讨会和会议。可供培训的主要研究领域包括：1。肠道炎症和感染的病理生理学，2.）肠道疾病的免疫机制，3.）肠癌中的细胞和分子异常，4.）肠道感染，5.）肝脏和肠道疾病中的受体生物学，6。胃肠道的粘液免疫，7.）肝纤维化，8.）营养素摄入量的调节，9.）疫苗开发和10.）胃肠道疾病的遗传因素。该培训计划将利用GI部门以及内科和外科其他实验室的杰出GI研究基地。培训计划还将受益于该医疗中心组织良好和资金充足的临床研究中心，以及两个消化疾病中心的临近，一个在哈佛医学院，另一个在马萨诸塞州总医院。

DESCRIPTION (provided by applicant): This is a competing continuation application for renewal of a training program in gastroenterology that was first funded in 1999. The objectives of this program are to provide research training for young investigators committed to a career in investigative gastroenterology or allied fields. The types of research training include basic, translational or clinical research, or combinations of these. Trainees may be MDs, MD-PhDs or PhDs who have finished clinical or graduate training and are seeking further research training in gastroenterology. The training period will last two to three years. Training will consist primarily of mentored research that will provide intense hands-on experience in research methods and experimental design, techniques of data collection, data interpretation including appropriate statistical analysis and preparation of research results for presentation and publication. An extensive menu of didactic courses, workshops, seminars and conferences will also be available. Trainees will be supervised by experienced research mentors with a wide range of interests and expertise from basic cellular and molecular biology to clinical research. A training committee composed of Drs. Lamont, Kelly, Afdhal, and Terhorst and one or two other training faculty will monitor each trainee's research progress. An extensive menu of didactic courses, workshops, seminars and conferences will also be available. The major areas of research available for training include: 1.) Pathophysiology of intestinal inflammation and infection, 2.) Immune mechanisms of bowel disease, 3.) Cellular and molecular abnormalities in intestinal cancer, 4.) Enteric infections, 5.) Receptor biology in hepatic and intestinal diseases, 6.) Mucosal immunity of the gastrointestinal tract, 7.) Hepatic fibrosis, 8.) Regulation of nutrient intake, 9.) Vaccine development and 10.) Genetic factors in GI diseases. The training program will take advantage of the outstanding GI research base within the GI Division and in other laboratories in the Departments of Medicine and Surgery. The training program will also benefit from the availability of a well organized and funded Clinical Research Center at this medical center, as well as the close proximity of two Digestive Disease Centers, one at Harvard Medical School and a second at Massachusetts General Hospital.