CORE--LABORATORY ANIMAL FACILITY

实验动物机构（IRB）负责采购、饲养、繁殖 和监测福克斯蔡斯癌症中心（FCCC）使用的所有脊椎动物。的 该设施目前由来自11个研究项目的42名同行评审、资助的研究人员使用 代表中心的三个部门。96%的受访者支持同行评议研究。该设施的工作人员提供动物相关的技术专长，并与使用该设施的各种研究实验室合作。该设施还保持六个基因定义的小鼠品系，这是该中心所独有的。这些机构得到了国际实验动物管理评估和认可协会（AAALAC）的全面认可，并被美国农业部指定为注册研究机构。研究动物设施占地14，204平方米。英尺动物空间分布在四层楼。六个独立的区域：1）研究啮齿动物的项目（包括转基因和免疫缺陷小鼠）; 2）无特定病原体（SPF）的繁殖屏障，用于为研究人员杂交和操纵特殊遗传品系的小鼠; 3）由国家实验室用于繁殖基础小鼠种群和近交品系的核菌落的毗邻SPF屏障建筑; 4）NMR大楼底层的一个区域，用于隔离和重新衍生中心新抵达的啮齿动物; 5）用于研究小鼠，大鼠，兔子和非洲爪蟾的常规住房;以及6）一楼的一个区域，用于饲养家养和野生捕获的土拨鼠和北京鸭。在过去五年中，研究用鼠笼的数量增加了两倍多，预计未来平均每年增加18%。该设施目前已满员。该中心在2003年增加了三个高密度通风啮齿动物架，并承诺今后每年都这样做;必须加快增加这些高密度架，以满足预期的研究增长。所有育种动物和所有转基因、免疫缺陷和再衍生动物现在都饲养在微型隔离笼中，这些区域在过去三年中都没有鼠病原体。动物护理和支持人员提供的技术服务几乎增加了三倍（287%），预计未来将继续扩大。

The Laboratory Animal Facility (LAP) is responsible for the procurement, husbandry, breeding and monitoring of all vertebrate animals used at the Fox Chase Cancer Center (FCCC). The Facility is currently used by 42 peer-reviewed, funded investigators from 11 research Programs representing all three Divisions of the Center. Ninety-six percent (96%) of LAP use supports peer-review research. The staff of the Facility provides animal related technical expertise to, and collaborates with, the various research laboratories using the Facility. The Facility also maintains six genetically defined mouse strains, which are unique to this Center. The Facilities are fully accredited by the Association for the Assessment and Accreditation of Laboratory Animal Care, International (AAALAC) and are designated as registered research Facilities by the U.S. Department of Agriculture. The Research Animal Facility contains 14,204 sq. ft. of animal space distributed over four floors. Six separate areas house: 1) research rodents on projects (including transgenic and immunodeficient mice) in micro isolators; 2) a specific pathogen-free (SPF) breeding barrier for crossing and manipulating special genetic strains of mice for research investigators; 3) an adjoining SPF barrier building used by the LAP for breeding nucleus colonies of foundation mouse stocks and inbred strains; 4) an area on the ground floor of the NMR building used for isolation and rederivation of newly arrived rodents at the Center; 5) conventional housing for research mice, rats, rabbits and Xenopus laevis; and 6) an area on the first floor for housing domestic and wild-caught woodchucks and Pekin Ducks. The number of research mouse cages has increased more than two-fold over the past five years and an average annual increase of 18% is projected for the future. The Facility is currently filled to capacity. The Center has added three high density ventilated rodent racks in 2003 and has committed to do the same each year in the future; the addition of these high-density racks must be accelerated to meet expected research growth. All breeding animals and all transgenic, immunodeficient, and rederived animals are now housed in microisolator cages, and these areas have all remained free of murine pathogens for the past three years. Technical services supplied by the animal care and support staff have increased almost three-fold (287%) and are expected to continue to expand in the future.