BABOON RESEARCH RESOURCE PROGRAM

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。描述(由申请人提供)：这项P40竞争更新计划建议继续最初拨款申请的目标，并扩大对以狒狒为模型的研究人员在生物医学和行为研究中的支持。研究人员不仅实现了最初拨款提案的目标，而且随着2002年7月授予R24，研究人员现在正在开发SPF浣熊资源。俄勒冈州里诺堡科学园设施于2001年3月竣工，并于2001年夏天全部投入使用。该设施提供了四个0.5英亩的室外畜栏和八个大型室内联排笼子，用于企鹅的集体住房。畜栏配备了大型攀爬结构和混凝土涵洞。有足够的空间让庞大的、多只雄性狒狒群体表现出物种典型的行为。每组有三只成年雄性和25到30只成年雌性狒狒，以及它们的幼崽和幼崽。这种社会安排对于Papio(P.)来说是典型的。野生的阿努比斯。后代留在畜栏里和父母在一起，直到需要他们进行研究。许多被分配进行研究的动物在研究期结束后被送回它们的家畜栏。这种情况是大多数疫苗方案的特点；在研究期间，从雷诺堡的畜栏中将狒狒作为一组移出，作为一组安置在动物资源附件中，然后作为一组返回雷诺堡设施。幼崽可以呆在同一个畜栏里，直到他们进入青春期。从四年前P40 Grant Support开始时的141只狒狒，发展到现在的284只，其中包括126只成年雌性巴布亚，14只成年雄性和149只婴儿和青少年。调查人员目前在里诺堡设施中安置了12名男性、115名成年女性及其婴儿和青少年后代。在去年的拨款年度，研究人员向OUHSC和外部研究人员提供了52只狒狒。在资助期的最后四年里，研究人员发表了18篇文章，并支持了美国国立卫生研究院(NIH)资助的12个外部直觉的研究项目。为了容纳越来越多的传统狒狒，未来的计划包括在现有的里诺堡设施基础上增加四个新的畜栏。其他计划包括建造一个单独的、六个畜栏的单元来安置SPF狒狒。调查人员正在增加两名合作调查人员，他们将扩大基于资源的研究。Uriel Blas-Machado，D.V.M.，Ph.D.将描述寄生原虫内阿米巴(Enamoeba(E.)一种地方性地存在于该群体和世界各地的许多群体中的溶组织动物。布拉斯-马查多博士将得到明尼苏达大学医学院医学系主任、医学博士乔纳森·拉夫丁的协助。拉夫丁博士是溶组性肠杆菌方面的专家，他得到了美国国立卫生研究院的资助，为人类开发了一种口服疫苗，以保护人类免受这种有机体的伤害。俄克拉荷马州立大学兽医病理学家威廉·A·梅尔博士将与加州国家灵长类动物研究中心的罗纳德·肯尼迪博士和克里斯托弗·J·米勒博士合作，开发试剂和方法，以评估狒狒对感染性病原体的细胞体液和细胞免疫反应。其主要任务是为美国国立卫生研究院资助的机构的研究人员提供健康和行为正常的狒狒，用于生物医学和行为研究。调查人员将提供两种选择，要么出售狒狒，要么出租它们，收取使用费，最终返回繁殖的蜂群。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. DESCRIPTION (provided by applicant): This P40 competitive renewal proposes to continue the aims of the initial grant application and expand the support of research investigators using baboons as models in biomedical and behavioral research. Not only have the investigators accomplished the aims of the initial grant proposal, but with the award of the R24 in July 2002 the investigators are now developing the SPF Baboon Resource. The OU Fort Reno Science Park Facility was completed in March of 2001 and became fully occupied by the summer of 2001. The facility provides four 0.5 acre outdoor corrals and eight large indoor gang cages for the group housing of baboons. The corrals are equipped with large climbing structures and concrete culverts. There is ample room for the large, multiple-male groups of baboons to exhibit species-typical behavior. Three adult males and from 25 to 30 adult female baboons with their infant and juvenile offspring populate each group. This social arrangement is typical for Papio (P.) anubis in the wild. The offspring remain in the corrals with their parents until they are needed for research. Many animals assigned to studies are later returned to their home corrals after the study period is completed. This scenario is characteristic of most vaccine protocols; baboons are removed in a group from a corral at Fort Reno, housed as a group at the Animal Resources Annex for the duration of the study, and then returned to as a group to the Fort Reno facility. The juveniles can remain together in the same corral until they reach puberty. The baboon colony has grown from 141 baboons at the outset of the P40 Grant support four years ago, to a colony of 284 baboons including 126 adult female baboons, 14 adult males, and 149 infants and juveniles. The investigators are presently housing 12 males, 115 adult females and their infant and juvenile offspring at the Fort Reno facility. During the last grant year, the investigators supplied 52 baboons to both OUHSC and outside research investigators. The investigators have published 18 articles and have supported National Institutes of Health (NIH) funded research programs at 12 outside intuitions during the last four years of the funding period. In order to accommodate increasing numbers of conventional baboons, the future plans include adding four new corrals to the present Fort Reno Facility. Additional plans include the construction of a separate, six-corral unit to house the SPF baboons. The investigators are adding two additional co-investigators who will expand the resource-based research. Uriel Blas-Machado, D.V.M., Ph.D., will characterize the parasitic protozoa Entamoeba (E.) histolytica that is endemic in the colony and in many colonies of baboons throughout the world. Dr. Blas-Machado will be assisted by the collaboration of Jonathan Ravdin, M.D., Chairman, Department of Medicine, University of Minnesota, College of Medicine. Dr. Ravdin is an expert in E. histolytica and has NIH funding to develop an oral vaccine for humans for protection from the organism. William A. Meier, D.V.M., Ph.D., Veterinary Pathologist at Oklahoma State University, will work with Dr. Ronald Kennedy and Dr. Christopher J. Miller, California National Primate Research Center, to develop reagents and methodologies to assess the cellular humoral and cellular immune response of baboons to infectious agents. The primary mission is to provide healthy and behaviorally normal baboons for biomedical and behavioral research to NIH-funded researchers at institutions across the United States. The investigators will offer the option of either selling baboons or leasing them for a use fee and ultimate return to the breeding colony.