Multidisciplinary training in cardiovascular biology

描述（由申请人提供）： HL 07954的竞争性更新，“心血管生物学的多学科培训”集中在宾夕法尼亚大学医学与工程研究所（IME）。IME将医学院（SOM）与物理，工程和计算科学联系起来，主要是在工程学院（SEAS）。该研究所的现代化研究实验室和核心实验室设施毗邻SOM和SEAS。赠款更新将支持6个前和7个博士后在跨学科心血管病理生理学的学员。18名主要教师（所有IME成员），代表分布在宾夕法尼亚大学SOM，费城儿童医院和SEAS的11个部门，进行基础和/或临床心血管研究，包括设备开发和转化研究。主要培训教师（9名教授，5名副教授和4名杰出的助理教授）在过去5年中获得了超过5000万美元（直接成本）的联邦研究赠款金。心血管研究的互补假设驱动和设计驱动发现方法被整合到从分子到体内的全方位尺度上。这种定量科学与基础生物医学研究的结合正在导致新的应用，这反映在专利披露和申请中。在过去的4年多里，该计划已成功地支持了8个插槽，涉及16名学员，他们在包括Science和PNAS在内的领先期刊上发表了42篇论文。更新建议适度增加插槽，其中一个专门指定为翻译临床研究员。要求在2-5年增加一个临床研究员职位。如果取得令人满意的进展，通常向每个受训者提供两年的支助。学员由7名教师组成的执行委员会在竞争性审查中选出，这是该计划跨学科性质的代表。受训人员的选择是根据学术记录，研究能力的质量，并致力于跨学科心血管生物学的研究。外部咨询委员会的三名成员定期访问和审查该计划。博士后（M.D.和/或Ph.D.）在培训期间，他们将获得很大的独立性。在撰写赠款和职业发展方面提供小组和个人辅导。博士前实习生（包括MD-PhD学生）在SOM的生物医学研究生组的研究生课程之一注册，或在SEAS的选择研究生组（生物工程，化学/生物分子工程或机械工程）。博士前学员至少完成一门，通常是几门心血管相关工程课程。所有学员都必须出席和参加基准跨学科研讨会系列（>40讲座/年）和双周粉笔谈话系列，每年运行11个月，并完成负责任的研究行为的培训。妇女（6名受训人员; 42份论文中的13份）和少数民族（1名受训人员; 42份出版物中的9份）的代表性问题得到了大力解决。已经实施了吸引新的少数族裔受训人员的新战略。(END（见摘要）

DESCRIPTION (provided by applicant): This competing renewal of HL07954, "Multidisciplinary Training in Cardiovascular Biology" is centered in the Institute for Medicine and Engineering (IME) at the University of Pennsylvania. The IME bridges the School of Medicine (SOM) to the physical, engineering and computational sciences principally in the School of Engineering (SEAS). The Institute's modern research labs and core laboratory facilities are adjacent to both SOM and SEAS. The grant renewal will support 6 pre- and 7 postdoctoral trainees in interdisciplinary cardiovascular pathophysiology. Eighteen principal faculty (all IME members), representing 11 departments distributed across Penn's SOM, Childrens Hospital of Philadelphia, and SEAS, conduct basic and/or clinical Cardiovascular research including device development and translational research. The principal training faculty (9 Professors, 5 Associate Professors, and 4 outstanding Assistant Professors) have been awarded more than $50m (direct costs) of Federal research grants over the past 5 years. Complementary hypothesis-driven and design-driven-discovery approaches to cardiovascular research are integrated to operate across a full spectrum of scales from the molecular to in vivo. This integration of quantitative sciences with fundamental biomedical research is leading to new applications as reflected in' patent disclosures and filings. During the past 4+ years, the program has successfully supported 8 slots involving 16 trainees who have authored 42 papers in leading journals including Science and PNAS. The renewal proposes a modest increase in slots with one specifically designated for a translational Clinical Fellow. An additional Clinical Fellow slot is requested for years 2-5. Two years of support are normally provided to each trainee, conditional on satisfactory progress. Trainees are selected in competitive review by an Executive Committee of 7 faculty that is representative of the interdisciplinary nature of the program. Trainee selections are made on the basis of academic record, quality of research abilities, and commitment to research in interdisciplinary cardiovascular biology. Three members of an External Advisory Committee visit and review the program periodically. Postdoctoral trainees (M.D.and/or Ph.D.) are expected to develop significant independence during their training period. Both group and individual mentorship in grant-writing and career development are provided. Predoctoral trainees (including MD-PhD students) are registered in one of the graduate programs of the Biomedical Graduate Group in the SOM or in select Graduate Groups of the SEAS (Bioengineering, Chemical/Biomolecular Engineering, or Mechanical Engineering). Predoctoral trainees complete at least one, and usually several, courses in cardiovascular-related engineering. All trainees are required to attend and participate in the benchmark Interdisciplinary Seminar Series (>40 lectures/year) and a biweekly Chalk Talk series that operate 11 months of the year, and to complete training in the responsible conduct of research. Women (6 trainees; 13 of 42 papers) and Minority (1 trainee; 9 of 42 publications) representation is strongly addressed. Novel strategies to attract new minority trainees have been implemented. (END OF ABSTRACT)