TIMED BREEDING CORE

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。杜兰国家灵长类动物研究中心的计时繁殖计划使用外源性黄体酮来控制排卵时间。在雌雄交配24天或31天后进行超声检查，以确定是否怀孕。这一程序可以有效地利用雄性，并通常在24小时内提供受孕日期。在2004-2005繁殖季节，饲养了33只印度原产恒河猴，结果怀孕4次。其中两次怀孕导致胎儿死亡。另外两名婴儿被分配到项目中，检查(1)母亲疟疾对胎儿发育和婴儿生长的影响，以及(2)新生儿SIV感染的影响。在过去的25年里，用黄体酮控制排卵后的妊娠率已经超过了60%。在上一次基地赠款更新现场访问期间提出的建议要求改变荷尔蒙和用于稀释它的油的供应。由于新试剂的溶解度低，造成了一个问题，此外，住房安排发生了重大变化，一些女性仍有哺乳婴儿。这些因素很可能是导致妊娠率下降的原因。在2005-2006年的繁殖季，它改用了黄体酮，并繁殖了21只繁育的黄金年龄的雌性。目前，已知怀孕4例，待定15例。在这个季节生产的婴儿将被分配到一个项目，检查新生儿SIV感染的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The timed-breeding program at the Tulane National Primate Research Center uses exogenous progesterone administration to control the time of ovulation. Ultrasonography is performed 24 or 31 days after placing the female with the male to establish pregnancy. This procedure allows for efficient use of the males and generally provides a conception date within a 24 hour time frame. In the 2004-2005 breeding season, 33 Indian-origin rhesus monkeys were bred resulting in 4 pregnancies. Two of the pregnancies resulted in fetal deaths. The other two infants were assigned to projects examining (1) effects of maternal malaria on fetal development and infant growth, and (2) effects of neonatal SIV infection. Over the past 25 years, the pregnancy rate following controlled ovulation through progesterone administration has been in excess of 60%. Recommendations made during the last Base Grant renewal site visit necessitated a change in the supply of the hormone and the oil used to dilute it. The new reagents posed a problem because of low solubility, moreover there were significant changes in the housing arrangements and several of the females still had nursing infants. It is most likely that these factors were contributing to the reduction in pregnancy rate. In the 2005-2006 breeding season, a switch was made to human progesterone and 21 prime breeding age females have been time bred. At the present time, there are 4 known pregnancies and 15 pending determination. Infants produced in this season will be assigned to a project examining the effects of neonatal SIV infection.