CORE--Inhalation Toxicology

在城市地区、靠近五大湖的地区吸入更易挥发的多氯联苯 正在进行疏浚，在垃圾填埋场和修复地点可能会导致神经疾病， 对动物和人类的生殖毒性和免疫毒性。项目1、2和3将调查 对大气中多氯联苯的毒理学反应。我们建议在ISBRP内建立吸入性毒理学核心 支持这些项目。我们的主要目标是为其他研究支持核心和项目提供服务 拥有最先进的动物设施和严格控制的吸入暴露在现实中 空气中多氯联苯同系物的混合物。为了实现这一目标，我们确定了四个具体目标： 目标1)在曝光室中产生受控的多氯联苯大气，并收集空气中的多氯联苯 通过蒸发常见的工业多氯联苯混合物来促进模型曝光的创建 混合体，(支持项目1、2、3、5和合成核心) 目的2)对实验室动物进行急性、亚急性和亚慢性吸入暴露，以确定 大气多氯联苯混合物和个别同系物(支持项目1、2和3) 目的3)为实验动物提供用于isbrp的啮齿动物，并实施质量控制。 监控他们的健康和福利的保障计划(支持项目1、2和3) 目的4)对暴露的、控制的和哨兵啮齿动物进行尸检，并将组织分发到项目 ISBRP的调查人员。(支持项目1、2和3) 吸入毒理学核心将在现有的吸入毒理学设施(ITF)内创建 环境健康科学研究中心，由6,000平方英尺的毗连实验室和 办公室。ITF因创新的动物模型和暴露传递系统而在全国范围内获得认可。一个完整的 提供一系列吸入毒理学、气溶胶科学和生物检测服务。吸入性 毒理学核心设备良好，可产生和量化多氯联苯蒸气或气雾剂； 大鼠急性、亚急性或亚慢性鼻腔吸入暴露；以及 暴露和反应的程度。新型印制电路板曝光输送系统的开发 以大气同系物为代表的混合物是一项基本的同时活动。

Inhalation exposure to the more volatile PCBs in urban areas, near the Great Lakes, in areas where dredging is occurring, and at landfills and remediation sites has the potential to cause neurological, reproductive, and immunological toxicity in animals and humans. Projects 1, 2, and 3 will investigate the toxicological responses to atmospheric PCBs. We propose an Inhalation Toxicology Core within the isbrp to support these Projects. Our primary goal is to serve the other research support cores and the projects with state-of-the-art animal facilities and rigorously controlled inhalation exposures to realistic mixtures of airborne PCB congeners. In order to achieve this goal, we have established four specific aims: Aim 1) Generate controlled PCB atmospheres in exposure chambers and collect airborne PCBs resulting from vaporization of common industrial PCB mixtures to facilitate the creation of a model exposure mixture, (supports Projects 1, 2, 3, 5 and the Synthesis Core) Aim 2) Perform acute, subacute and subchronic inhalation exposures to laboratory animals to defined mixtures of atmospheric PCBs and to individual congeners, (supports Projects 1, 2, and 3) Aim 3) Provide a rodent vivarium for experimental animals used for the isbrp and execute a quality assurance program to monitor their health and welfare, (supports Projects 1, 2, and 3) Aim 4) Perform necropies on exposed, control and sentinel rodents and distribute tissues to project investigators in the isbrp. (supports Projects 1, 2, and 3) The Inhalation Toxicology Core will be created within the existing Inhalation Toxicology Facility (ITF) of the Environmental Health Sciences Research Center which consists of 6,000 ft2 of contiguous laboratories and offices. The ITF is nationally recognized for innovative animal models and exposure delivery systems. A full array of inhalation toxicology, aerosol science, and bioassay services are rendered. The Inhalation Toxicology Core is well equipped for generating and quantifying PCB vapors or aerosols; for performing nose-only inhalation exposures of rats in acute, subacute or subchronic protocols; and for determining the degree of exposure and response. The development of innovative exposure delivery systems for PCB mixtures representative of atmospheric congeners is an essential concurrent activity.