UCSD Cancer Center Training Program in Drug Development

描述（由申请人提供）：这是一个新的两年博士后培训项目的申请，在癌症研究，更具体地说，在新的癌症药物的开发，在丽贝卡和约翰摩尔斯加州大学圣地亚哥分校癌症中心，一个NCI指定的综合癌症中心。这16名教员分别来自医学院和加州大学圣地亚哥分校斯卡格斯药学院的医学部、病理学系、外科学系和药理学系。每位教师导师都是癌症中心的参与成员，对癌症或癌症相关研究基金进行同行评审。这个项目很好地融入了癌症中心和加州大学圣地亚哥分校的其他癌症相关活动。目标是在这个为期两年的项目中招募并维持8名医学博士和博士科学家，从事癌症学术研究，重点是针对发育治疗的转化研究。受训者将被要求通过医学院管理和NIH资助的CREST项目学习课程；由该培训计划协调的系列讲座、癌症中心和部门研讨会、学员期刊俱乐部，以及定期召开的会议，以扩大他们的癌症研究培训和观点。所有参与的教师都在进行转化研究，并被选中是因为他们对新的癌症治疗方法感兴趣。该项目将采用相关的NCI拨款项目，包括针对癌症差异的癌症中心/少数族裔机构合作项目的U56计划拨款，以及针对学术公私合作项目（AP4）的未决U54拨款申请。它还将使用最近开放的摩尔癌症中心大楼，一个27万平方英尺的最先进的多用途结构，将临床护理与基础和预防研究相结合。有办法确保所有受训者在负责任的研究行为和科学诚信的原则方面得到适当的指导。

DESCRIPTION (provided by applicant): This is an application for a new two-year postdoctoral training program in cancer research and more specifically in the development of new cancer agents, at the Rebecca and John Moores UCSD Cancer Center, an NCI designated comprehensive cancer center. The 16 faculty members come from the departments of Medicine, Pathology, Surgery, and Pharmacology within the medical school and the Skaggs UCSD School of Pharmacy and Pharmaceutical Sciences. Each faculty mentor is a participating member of the Cancer Center, having peer reviewed cancer or cancer-related research funding. This program is well integrated into the other cancer related activities of the Caner Center and of UCSD. The goal is to recruit and maintain 8 MD and PhD scientists in this two year program for careers in academic cancer research, with an emphasis on translational research targeted at developmental therapeutics. Trainees will be required to take courses through the medical school managed and NIH funded CREST program; a lecture series coordinated by this training program, Cancer Center and departmental seminars, a journal club for the trainees, and regularly scheduled conferences to expand their cancer research training and perspectives. All of the participating faculty are conducting translational research and have been selected because of their interest in new cancer therapeutics. This program will employ related NCI grant projects including a U56 planning grant for a cancer center/minority institution partnership program in cancer disparities, as well as a pending U54 grant application for an Academic Public, Private Partnership Program (AP4). It will also employ the recently opened Moores Cancer Center building, a 270,000 sf state of the art multi-use structure combining clinical care with basic and prevention research. Methods are in place to ensure that all trainees are properly instructed in the principles of responsible conduct of research and scientific integrity. MD fellows who are interested in academic research related to cancer, and committed to at least two years of research training will be recruited from the Hematology/Oncology, Surgery and Radiology fellowship programs here at UCSD as well as nationwide. PhD applicants come to us from within UCSD and from other research universities with strong backgrounds in biology, biochemistry, chemistry and molecular or cellular biology, and choose to develop their skills related to developing new cancer therapeutics. Special efforts will be made through our partnership grant and other vehicles to recruit and retain exceptional minority and women candidates to the program.