MOLECULAR NEUROBIOLOGY OF FEAR IN MAMMALS

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。雷斯勒实验室专注于研究恐惧学习的分子和细胞机制，以及小鼠模型中恐惧的消退过程。雷斯勒实验室利用分子遗传学的力量，开始了解小鼠模型中恐惧和消除恐惧的分子生物学、神经回路和行为生物学。在过去的一年里，这项工作很可能成功地为Ressler实验室收到了R01(在研究部分得分3%)，题为通过NIDA的杏仁核中GABA(A)功能的分子调节，以及多个摘要的呈现和多个手稿的出版。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Ressler lab is focused on the molecular and cellular mechanisms of fear learning and the process of extinction of fear in mouse models. The Ressler lab has used the power of molecular genetics to begin to understand the molecular biology, the neural circuitry, and the behavioral biology of fear and extinction of fear in mouse models. Within the last year this work has led to the likely successful receipt of an R01 for the Ressler lab (3% scored at study section), entitled ¿The Molecular Regulation of GABA(A) Function in Amygdala¿ through NIDA, as well as the presentation of multiple abstracts and publication of multiple manuscripts.