THE ROLE OF NEUREGULIN AND ITS RECEPTOR, ERBB4, IN CONDITIONED FEAR LEARNING

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。这个项目是与莫尔豪斯医学院的拜伦·福特博士合作的，研究了控制杏仁核内的神经调节蛋白（NRG）系统的影响。我们使用带产生Cre的慢病毒的封闭NRG小鼠和在野生型小鼠中产生显性阴性ErbB4的慢病毒来检测杏仁核中的神经调节蛋白功能和ErbB4受体功能。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project in collaboration with Byron Ford, PhD, of Morehouse School of Medicine examines the effects of manipulating the neuregulin (NRG) system within the amygdala. We have used a floxed NRG mouse with a Lentivirus producing Cre as well as a lentivirus that produces a dominant-negative ErbB4 in wild-type mice to examine Neuregulin functioning and ErbB4 receptor functioning in amygdala.