SPECIFIC PATHOGEN FREE MACAQUE BREEDING AND RESEARCH PROGRAM

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。NEPRC SPF计划非常有成效，在过去的九年里一直保持无特定病原体。这些组中的所有动物都没有病原体。目前大约有500只动物在繁殖后宫。繁殖群最多由10只雌性和1只成年雄性组成。NEPRC的育种计划包括只有B型疱疹抗体阴性的无特定病原体的动物。定期对所有成年和幼年动物进行目标逆转录病毒的筛查是维持和派生SPF繁育群的关键。现有的群体至少每半年进行一次筛查，除非殖民地出现意想不到的临床疾病而需要更频繁的检测。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The NEPRC SPF program is very productive and has remained specific pathogen-free for the past nine years. All of the animals in the groups stayed pathogen free. There are currently approximately 500 animals in breeding harem groups. The breeding groups consist of a maximum of 10 females and 1 adult male. The breeding program at the NEPRC consists of specific pathogen free animals with Herpes B antibody negative animals only. Regular screening of all animals both adults and juveniles for the target retroviruses is a key to maintaining and deriving SPF breeding group. Established groups are screened at least semi-annually unless more frequent testing is warranted by an unexpected clinical illness in the colony.