FOURIER DOMAIN LOW COHERENCE INTERFEROMETRIC MICROSCOPY

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心机构，不一定为研究者机构。我们正在研制一种傅里叶域反射相位成像显微镜。一个共同的路径相位参考检测方案允许在kHz带宽的细胞位移的埃尺度测量。双折射光学器件能够实现高横向和纵向分辨率。 可以通过扫描样品或光束来执行二维成像。反射相位测量将用于测量小的相移和膜波动，这是已知的伴随神经元和神经纤维中的电活动。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We are developing a Fourier domain reflectance phase imaging microscope. A common-path phase-referenced detection scheme allows angstrom-scale measurements of cell displacements at kHz bandwidths. Birefringent optics enable high transverse and longitudinal resolution. Two-dimensional imaging can be performed by scanning the sample or the beam. Reflection phase measurements will be used to measure small phase shifts and membrane fluctuations which are known to accompany electrical activity in neurons and nerve fibers.