CNS DEFICITS: INTERACTION OF AGE & ALCOHOLISM

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。目的：该项目的目的是继续分析之前在卢卡斯中心收集的纵向和横断面MRI和行为数据。我们完成了对纹状体（尾状核、壳核、伏隔核）和基底前脑[内侧隔/对角线带（MS/BD）]结构的体积测量的进一步分析，这些结构是在酒精中毒（n = 25）、Korsakoff综合征（n = 6）、酒精性精神分裂症共病（n = 19）和健康对照（n = 51）患者的3D脑部扫描中测量的。无论清醒时间长短，酗酒者的尾状核和壳核体积都比对照组小。然而，伏隔核对最近的酒精暴露表现出明显的敏感性，最近饮酒的缺陷比清醒的酗酒者更大（无论他们是否患有精神分裂症），而长期清醒的KS没有缺陷。酗酒者壳核体积与握力呈正相关，MS/DB体积与言语工作记忆呈正相关，不受年龄标准化MS/DB与年龄负相关的影响。KS组MS/DB也降低。结论：嗜酒者伏隔核可随清醒而恢复。酒精中毒患者壳核和质谱/脑脊液体积的缺陷具有功能意义。MS/DB体积损失和潜在的伴随胆碱能损害也可能导致KS遗忘综合征。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Aims: The aims of this project are to continue analysis of longitudinal and cross-sectional MRI and behavioral data previously collected at the Lucas Center Methods and Results: We have completed further analysis of volumetric measures of striatal (caudate nucleus, putamen, nucleus accumbens) and basal forebrain [medial septum/diagonal band (MS/BD)] structures measured on 3D brain scans obtained from patients with alcoholism (n = 25), Korsakoff¿s Syndrome (n = 6), schizophrenia comorbid for alcoholism (n = 19) and healthy controls (n = 51). Volumes of caudate and putamen were smaller in the alcoholics than the controls, regardless of length of sobriety. However, the nucleus accumbens showed marked sensitivity to recent alcohol exposure, with greater deficits in recently drinking than sober alcoholics (whether or not they were comorbid for schizophrenia) and no deficits in long sober KS. Among alcoholics, putamen volume was positively correlated with grip strength and MS/DB volume was positively correlated with verbal working memory independently of the negative association between age-standardized MS/DB and age in alcoholics. MS/DB was also reduced in KS. Conclusions: The nucleus accumbens may show recovery with sobriety among alcoholics. Deficits in putamen and MS/DB volumes in alcoholism have functional significance. MS/DB volume loss and potential accompanying cholinergic compromise may also contribute to the KS amnesic syndrome.