TREATMENT OPTIONS FOR TYPE 2 DIABETES IN ADOLESCENTS AND YOUTH (TODAY)

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。今天将根据10-17岁2型糖尿病(Ty2 DM)儿童的血糖控制情况，评估三种治疗方案的安全性和有效性--单用二甲双胍；二甲双胍加罗格列酮；以及二甲双胍加生活方式计划，以减轻体重和增加体力活动--根据治疗失败的时间。次要目的：比较和评价ARM的安全性和成本-效果；评估个人和家庭行为对治疗反应的影响；比较ARM对2型糖尿病的病理生理学(β细胞功能、胰岛素抵抗、身体成分、营养、体力活动、有氧健身、心血管危险因素、微血管并发症、生活质量和心理结果)的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. TODAY will evaluate the safety and efficacy of three treatment regimens -- metformin alone; metformin plus rosiglitazone; and metformin plus a lifestyle program to reduce weight and increase physical activity -- by time to treatment failure based on glycemic control in children age 10-17 with Type 2 diabetes (Ty2DM). Secondary aims: compare and evaluate the arms' safety and cost- effectiveness; evaluate influence of individual and family behaviors on treatment response; and compare the arms' effects on pathophysiology of Ty2DM (beta cell function, insulin resistance, body composition, nutrition, physical activity, aerobic fitness, cardiovascular risk factors, microvascular complications, quality of life and psychological outcomes).