JDRF STUDY OF AUTOIMMUNITY

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。该建议解决了目前知识方面的三个主要差距。首先，缺乏一种可接受且可重复的糖尿病特异性T细胞活性测量方法；第二，除了HLA（人类白细胞抗原基因，它赋予1型糖尿病和其他自身免疫性疾病的风险，其中的亚群已被很好地描述为与1型糖尿病风险的关联）之外，在识别糖尿病相关基因方面存在困难；第三，需要改善参加临床试验的人的代谢结果测量。因此，我们将使用新方法在有糖尿病风险或患有糖尿病的受试者中充分表征这些参数。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The proposal addresses three major gaps in current knowledge. First, the absence of an accepted and reproducible measure of diabetes specific T cell activity; second, the difficulties in identifying diabetes-associated genes in addition to HLA, (Human Leukocyte Antigen genes, which confer risk for type 1 diabetes as well as other autoimmune diseases, subsets of which have been well described in terms of their association with risk of type 1 diabetes); third, the need to improve metabolic outcome measures for people enrolled in clinical trials. We will therefore fully characterize these parameters in subjects at risk for or with diabetes using novel methods.