ZINC AND CHILD-MATERNAL BRAIN FUNCTION IN SOUTHERN ETHIOPIA

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。缺锌是一个全球性的公共卫生问题，对身体和认知发育、生长、畸形、神经行为发育、出生胎龄、新生儿免疫状态、婴儿发病率等产生广泛的不利影响。锌缺乏症在埃塞俄比亚农村尤为严重，因此它是研究膳食锌补充的一个引人注目的地点。假设对孕妇和婴儿长期补充锌，锌的状况将会改善，婴儿发病率和发育迟缓等公共卫生问题也会改善。这项试点研究将为埃塞俄比亚阿瓦萨、南部国家、民族和民族地区的农村社区提供基本的基线数据。这些研究不包含任何干预或治疗。基线数据将是母亲-婴儿和母亲-幼儿对的横断面数据，包括饮食摄入、营养状况、膳食锌需求和脑功能测量等信息。这一基础信息将促成一项主要的R01拨款提案的发展，该提案旨在长期研究在怀孕的第二和第三个三个月到生命的头两年提供最佳量的生物可利用锌的影响。试点和长期研究都涉及埃塞俄比亚的德布布大学，需要通过与俄克拉何马州立大学和俄克拉何马州立大学合作开发必要的资源，包括人力资源。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Zinc deficiency is a global public health problem with a wide range of adverse effects on physical and cognitive development, growth, malformations, neurobehavioral development, gestational age at birth, neonatal immune status, infant morbidity, and more. Zinc deficiency is particularly acute in rural Ethiopia and thus it is a compelling site for studies of dietary zinc supplementation. With long-term supplementation to both pregnant mothers and infants, it is hypothesized that zinc status will improve, as will public health issues such as infant morbidity, and stunting. This pilot study will provide essential baseline data for rural communities in Awassa, Southern Nations, Nationalities, and Peoples Region of Ethiopia. These studies do not contain any intervention or treatment. The baseline data will be cross-sectional data from mother-infant and mother-toddler pairs and will include information on dietary intake, nutritional status, dietary zinc requirements, and on measures of brain function. This cornerstone information will lead to the development of a major R01 grant proposal for a long-term study on the effects of provision of an optimal quantity of bioavailable zinc during the 2nd and 3rd trimesters of pregnancy through the first two years of life. Both the pilot and long-range studies involve Debub University in Ethiopia and require development of the necessary resources, including human, through collaboration with Oklahoma State University and UCHSC.