FMRI AND EMOTION IN PERSONALITY DISORDER PATIENTS

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。情感不稳定是边缘型人格障碍（BPD）的核心特征。它可能与严重的功能损害、高服务利用率和负面的临床结果有关。这种症状可能与情绪刺激的神经处理中的潜在障碍有关。在情绪处理的神经生物学方面的研究中，最近的一项进展是将受试者暴露在功能磁共振成像中的情绪刺激下。这种类型的范式一直与大脑皮层下和新皮层区域的激活有关，这些区域已知参与情绪体验和情绪信息的处理。情感性障碍患者在这些大脑区域表现出改变的反应，包括杏仁核、前扣带、眼窝前额皮质和背外侧前额皮质。在这些疾病中，杏仁核和前扣带皮层之间可能存在一种特别重要的情绪调节功能关系。相反，在BPD中，区域大脑对情绪刺激的激活模式尚未得到很好的研究。该申请建议使用功能磁共振成像（fMRI）启动对情绪刺激的大脑区域反应的初步研究，并预测BPD患者在杏仁核和扣带皮层的激活区域与正常对照相比将表现出差异。这项研究的结果将用于随后检验这种假设的脑功能障碍在症状（即诊断类别内）和诊断（即跨诊断类别）方面的临床特异性，并表征情感不稳定额叶模型中情绪处理障碍的时空动态。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Affective instability is a core feature of borderline personality disorder (BPD). It may be associated with significant functional impairment, high rates of service utilization, and negative clinical outcomes. This symptom may be related to an underlying disturbance in the neural processing of emotional stimuli. A recent development in the study of neurobiological aspects of emotion processing involves exposing a subject to emotional stimuli in functional magnetic resonance imaging. This type of paradigm is consistently associated with activation of subcortical and neocortical brain regions known to be involved in emotional experience and processing of emotional information. Patients with affective disorders exhibit altered responses in several of these brain regions, including amygdala, and anterior cingulate, orbitofrontal and dorsolateral prefrontal cortices. A particularly important functional relationship for emotion regulation may exist between the amygdala and anterior cingulate cortex in these disorders in these disorder. In contrast, the pattern of regional brain activation to emotional stimuli has not been well-investigated in BPD. This application proposes to use fMRI to initiate a pilot study of regional brain response to emotional stimuli, with the prediction that BPD patients will show differences in the activation of areas of the amygdala and cingulate cortex compared to normal controls. Results from this study will be utilized to later examine the clinical specificity of this hypothesized brain brain dysfunction for the symptoms (ie within diagnostic category) and for the diagnosis (ie across diagnostic category) of BPD, and to characterize the temporal and spatial dynamics of emotion processing disturbance in a frontolimbic model of affective instability.