BIOCHEMICAL PARAMETERS OF BONE METABOLISM--AGE AND SEX CONTRASTS

工作总结：已经证实了骨密度相关的变化 在男性和女性中。年龄和性别相关的差异激素， 参与骨转换的营养和生理变量是 在阐明正常衰老过程中骨生理学变化方面具有重要意义， 疾病具体来说，年龄和性别与身体变化的关系 组成，既作为肥胖的标志，也作为体重的衡量标准， 骨承受负荷是影响骨状况和骨代谢率的重要因素， 变化 骨量变化最剧烈的发生在 更年期，身体成分，骨量和骨标志物的变化 在一组围绝经期妇女中进行了研究 招募到巴尔的摩老龄化纵向研究，谁将是 每隔3个月随访一次。 这些 研究将允许解释之前发生的变化 到月经停止前后， 这只能在前瞻性纵向研究中才能理解。 初步结果比较了27名绝经前妇女（血浆 卵泡刺激素（FSH）水平均低于30 IU）， 随访至少一年，其中21名妇女被归类为 围月经期（至少有一次FSH大于30，前一次FSH之后） 不到30岁），并在他们的研究结束后至少随访一年。 初始FSH升高。 绝经前的妇女没有 通过DEXA扫描评估的身体组成的显著变化， 围绝经期妇女的体重明显增加， 脂肪和脂肪百分比。 这些进入 绝经早期也有明显的骨矿物质丢失 从他们的腰椎，而那些妇女谁仍然绝经前， 实际上仍然显著增加了骨矿物质的量， 脊椎 两组患者的髋部骨矿物质都在流失， 在围月经期组中尚未观察到加速这些变化都 发生在月经完全停止之前，并表明， 在更年期的过渡期， 以前认为。

Summary of work: Age-related changes in bone mass have been demonstrated in both men and women. Age and sex related differences hormones, nutritional and physiological variables involved in bone turnover are important in elucidating changes in bone physiology in normal aging and disease. Specifically, the relationship age and sex to changes in body composition, both as a marker of obesity and as a measure of the weight bearing load on bone are important factors in bone status and rates of change. The most dramatic rates of change in bone mass occur at the menopause, and changes of body composition, bone mass, and bone markers and hormones are being investigated in a cohort of perimenopausal women recruited to the Baltimore Longitudinal Study of Aging, who will be followed at 3 month intervals as they traverse the menopause. These studies will allow for the interpretation of the changes that occur prior to and immediately around the time of the cessation of menses, changes that can only be appreciated in a prospective longitudinal study. Preliminary results compared 27 women who remained premenopausal (plasma Follicle Stimulating Hormone ( FSH ) levels all less than 30 IU) and who were followed for at least one year, with 21 women who were classified as perimenopausal ( at least one FSH greater than 30 after a previous FSH less than 30) and who were followed for at least one year after their initial elevated FSH. The women who e remained premenopausal had no significant change in body composition as assessed by DEXA scanning while the perimenopausal women had significant increases in the amount of body fat as well as their percent fat. These women who are entering the earliest stage of the menopause also had significant lose of bone mineral from their lumbar spine while those women who remained premenopausal were actually significantly still increasing the amount of bone mineral in the spine. Both groups were losing bone mineral at the hip, with no acceleration yet seen in the perimenopausal group These changes all occured prior to the complete cessation of menstruation, and indicate that changes are occuring earlier in the transition across the menopause than previously thought.