PSYCHOLOGICAL/BIOLOGICAL CHARACTERIZATION OF SMOKING WITHDRAWAL IN ALCOHOLICS

酗酒者比不吸烟的人更有可能吸烟 酗酒问题。在这个方案中，我们正在研究神经递质 近期戒酒的尼古丁戒断者的代谢物变化 戒断由血清尼古丁/可替宁浓度证实。 继续吸烟的酗酒者或不吸烟、不酗酒的人 非吸烟者和吸烟者组成了对比组。结果是 提示尼古丁期间中枢去甲肾上腺素能周转减少 戒烟。此外，中枢多巴胺能 不吸烟酗酒者的流失率。这些变化背后的机制 以及已知的影响其他神经递质的相关变化 酗酒也在调查中。结果表明， 单胺类物质在体内可能很重要 药物成瘾的神经生物学机制。

Alcoholics are more likely to smoke cigarettes than individuals without a drinking problem. In this protocol, we are studying neurotransmitter metabolite changes in recently abstinent alcoholics undergoing nicotine withdrawal verified by serum nicotine/cotinine concentrations. Alcoholics who continue to smoke or who are nonsmokers, nonalcoholic nonsmokers and smokers, make up the comparison groups. The results suggest decreased central noradrenergic turnover during nicotine withdrawal. In addition, there is increased central dopaminergic turnover in nonsmoking alcoholics. Mechanisms underlying these changes and allied changes in other neurotransmitters known to be affected by alcoholism are also being investigated. The results suggest that monoamines may be important in the neurobiological mechanisms of drug addiction.