ADVANCED HIGH-RESOLUTION TWO-DIMENSIONAL X-RAY DETECTOR FOR MAMMOGRAPHY

描述（由申请人提供）：该项目的目标是提高数字乳房x线摄影的图像质量，降低成本。我们将开发一种基于新型玻璃陶瓷材料的乳腺x线摄影（CR）系统。这些玻璃材料可以比现有的光刺激荧光粉材料更便宜并获得更好的性能。它们是透明的，因此不会像多晶材料那样，由于晶界的光散射而导致分辨率下降和噪声增加。具体而言，我们将：1)通过差示扫描量热法、扫描和透射电子显微镜、x射线衍射、光致发光、x射线激发发光和x射线吸收近边结构进行结构研究。2)优化用于CR乳房x线造影的TSP材料：a)提高TSP的PSL信号，即增益，同时保持乳房x线造影所需的高x射线吸收率和高分辨率。b)尽量减少读数所需的刺激曝光（激光功率）。c)最小化TSP材料中的增益波动噪声和结构噪声。d)研制用于全视场数字化乳房x线摄影的大画幅TSP板。3)设计并构建TSP读出系统。a)设计并制造一个台式读出装置。b)确定设计参数，搭建全场高速读出装置。4)通过以下方式对新的计算机放射成像（CR）系统进行表征和基准测试：a)建立基于tsp的CR系统的DQE理论模型。b)测量新系统的系统响应、调制传递函数（MTF）、噪声功率谱（NPS）、噪声等效量子（NEQ）、探测量子效率（DQE）和对比度细节可探测性。c)测量GE Essential FFDM系统和FujiFilm CR乳房x光系统的系统响应、MTF、NPS、NEQ、DQE和对比度细节可检测性。d)将新系统的性能与GE Essential和FujiFilm CR系统进行比较。

DESCRIPTION (provided by applicant): The goal of this project is to improve the image quality and reduce the cost of digital mammography. We will develop a computed radiography (CR) system for mammography based on novel glass ceramic materials. These glass materials can be less expensive and attain better performance than existing photostimulable phosphor materials. They are transparent and, therefore, do not suffer from loss of resolution and increase in noise due to light scattering from grain boundaries, as do polycrystalline materials. Specifically, we will: 1) Perform structural investigations via Differential Scanning Calorimetry, Scanning and Transmission Electron Microscopy, X-Ray Diffraction, Photoluminescence, X-ray excited Luminescence, and X-ray Absorption Near-Edge Structure. 2) Optimize the TSP material for the application in CR mammography: a) Improve the PSL signal, i.e. gain, of the TSP while maintaining high x-ray absorption and high resolution required for mammography. b) Minimize the stimulating exposure (laser power) required for readout. c) Minimize gain-fluctuation noise and structure noise in the TSP materials. d) Develop a large-format TSP plate for full-field digital mammography. 3) Design and construct a readout system for TSP. a) Design and build a benchtop readout apparatus. b) Determine design parameters and build a full-field, high-speed readout apparatus. 4) Characterize and benchmark the new computed radiography (CR) system by: a) Developing a theoretical model for the DQE of the TSP-based CR system. b) Measuring the system response, modulation transfer function (MTF), noise power spectra (NPS), noise equivalent quanta (NEQ), detective quantum efficiency (DQE), and contrast detail detectability of the new system. c) Measuring the system response, MTF, NPS, NEQ, DQE, and contrast detail detectability for a GE Essential FFDM system and FujiFilm CR mammography systems. d) Comparing the performance of the new system with the GE Essential and FujiFilm CR systems.