Graduate Training at the Chemistry Biology Interface

描述（由申请人提供）：该提案要求为化学/生物学接口（CBI）的一项倡议提供资金。 该计划于1998年在UMBC开始，为化学专业的学生提供了一个熟悉生物科学的机会，并为生物科学专业的学生提供了熟悉化学的机会。 到目前为止，11名高素质的学生已经被招募到这个计划，所有这些学生都表现得很好。 UMBC CBI课程的学生将在博士学位课程中注册。计划在化学（化学），联合生物化学博士。项目（BIOC）与马里兰州，巴尔的摩（UMB）的大学或博士学位。分子和细胞生物学（MOCB） 这些学生的论文导师可以来自三个UMBC部门（化学与生物化学，生物科学或化学与生物化学工程）和UMB（生物化学与分子生物学系）的一个部门。 跨学科的培训将通过让每个学生（1）在生物学方向的实验室和化学方向的实验室完成轮换;（2）在两个学科的高级课程;（3）报名参加题为“化学/生物学接口问题”的年度课程;（4）参加年度CBI研讨会;及（5）出席研讨会和会议，重点是跨学科的工作在CBI。参与教师的研究兴趣跨越各种各样的领域，从光化学，通过生物分析化学，合成化学和酶学结构生物学，细胞生物学和免疫学。 目前学生在该计划的研究领域是：核糖体蛋白S3，S4和S5在翻译中的作用;通过分子生物学和质谱分析表征小热休克蛋白Hsp 17.7;分离和检测不同的核酸构象和序列;时间分辨线性二色光谱的应用; 3-氧代-5-雄烯-3，17-二酮异构化反应的活化焓和活化熵5-类固醇异构酶; HIV-1？-内蛋白质-RNA复合物的表征高分辨率FT-ICR质谱法;生物活性硫代化合物体外微透析的先进应用;内源性肿瘤抗原呈递中MHC II类肽加载的机制; HIV-2基因组识别的NMR研究。 学员的定期会议将确保他们在CBI接触到各种各样的主题。

DESCRIPTION (provided by applicant): This proposal requests funding for an initiative at the Chemistry/Biology Interface (CBI). This program was started at UMBC in 1998 to provide an opportunity for chemistry students to become conversant in the biological sciences and students in the biological sciences to become familiar with chemistry. To date, eleven highly qualified students have been recruited to this program, and all of these students are performing very well. Students in the UMBC CBI program will be registered in either the Ph.D. program in chemistry (CHEM), the joint biochemistry Ph.D. program (BIOC) with the University of Maryland, Baltimore (UMB) or the Ph.D. program in Molecular and Cell Biology (MOCB). Dissertation mentors for these students can come from three UMBC departments (Chemistry & Biochemistry, Biological Sciences or Chemical & Biochemical Engineering) and one department at UMB (Department of Biochemistry & Molecular Biology). Cross-disciplinary training will be ensured by having each student (1) complete a rotation in both a biologically-oriented laboratory and a chemically-oriented laboratory; (2) take an advanced course in both disciplines; (3) enroll in a yearly course entitled "Issues at the Chemistry/Biology Interface;" (4) participate in an annual CBI Workshop; and (5) attend seminars and meetings with a focus on interdisciplinary work at the CBI. Research interests of the participating faculty span a wide variety of areas from photochemistry, through bioanalytical chemistry, synthetic chemistry and enzymology to structural biology, cell biology and immunology. Research areas of current students in the program are: The Role of Ribosomal Proteins S3, S4, and S5 in Translation; Characterization of Small Heat Shock Protein Hsp 17.7 via Molecular Biology and Mass Spectrometry Analysis; Separation and Detection of Varying Nucleic Acid Conformations and Sequences; Applications of Time-Resolved Linear Dichroism Spectroscopy; Activation Enthalpies and Entropies for Isomerization of 5-Androstene-3,17-dione by 3-Oxo-?5-steroid Isomerase; Characterization of Protein-RNA Complexes within the HIV-1 ?-Site by High Resolution FT-ICR Mass Spectrometry; Advanced Applications of In Vitro Microdialysis for Bioactive Thiocompounds; Mechanisms of MHC class II peptide loading in endogenous tumor antigen presentation; NMR Studies of HIV-2 Genome Recognition. Regular meetings of the trainees will ensure that they are exposed to a wide variety of topics at the CBI.