Training Program in Biostatistics and Cancer Research

描述（由申请人提供）：项目概述：本申请是在生物统计学与癌症研究的具体重点培训计划的延续。该培训计划每年支持6名学生。 生物统计学的实践正在发生变化，特别是在癌症研究领域。在过去的二十年里，对细胞生长和发育的分子、生物化学和遗传成分的发现改变了我们对正常细胞癌变和转移的理解。多学科研究团队是现代抗癌方法的核心，生物统计学家越来越多地参与其中。这样的团队合作需要统计学家熟悉分子生物学家、病理学家，当然，如果合作研究者小组要成功的话，还有临床肿瘤学家。因此，有效的生物统计合作需要在统计学、概率、计算方法以及癌症生物学和医学伦理学方面进行广泛的培训。莱斯大学统计系和德克萨斯大学定量科学系的各个系。D.安德森癌症中心（UTMDACC）与他们在临床和基础科学方面的合作者联手开发了一个独特的培训计划，结合各自的优势，培训癌症研究中的生物统计学家。生物统计学培训计划的目标是培养新一代的生物统计学家，他们将与现代癌症研究中的生物医学研究人员并肩工作。我们的计划旨在为学员提供统计和概率方面的严格培训;基础和临床癌症研究的实践经验;以及癌症和医学研究伦理的生物学方面的培训。 该计划的学生遵循博士预期的标准课程。在赖斯统计系的学生，在生物统计学，生物学和伦理学的额外课程，以及在这两个机构的特别研讨会和讲习班。凭借贝叶斯方法，决策理论，癌症临床试验，癌症筛查，生存分析，统计遗传学，基因组学，生物信息学和统计计算的教师专业知识，学员将获得现代癌症研究所需的生物统计学的广泛背景。暑期实习和实验室轮换为学生的培训提供了实践经验。 相关性：将莱斯大学和UTMDACC的教育资源与实践经验相结合，将使学员在完成学业后能够与生物医学研究人员一起为癌症研究做出根本性贡献。这种密切的合作将导致更有效的研究设计和数据分析，使治疗理论更快地转化为临床应用。

DESCRIPTION (provided by applicant): Project Summary: This application is for continuation of a training program in biostatistics with a specific focus on cancer research. The training program supports six students each year. The practice of biostatistics is changing, especially in the area of cancer research. Discoveries over the last two decades into the molecular, biochemical, and genetic components of cell growth and development lave changed our understanding of what makes a normal cell become cancerous and then metastasize. Multidisciplinary research teams are at the heart of modern approaches to fighting cancer, and biostatisticians more and more are a part of such teams. Such teamwork requires that the statistician be conversant with molecular biologists, pathologists, and, of course, clinical oncologists if the group of co-investigators is to succeed. Effective biostatistical collaboration thus requires broad training in statistics, probability, computational methods, as well as cancer biology and medical ethics. The Department of Statistics, Rice University, and departments in the Division of Quantitative Sciences at the University of Texas M. D. Anderson Cancer Center (UTMDACC) have joined forces with their collaborators in the clinical and basic sciences to develop a unique training program that combines their respective strengths to train biostatisticians in cancer research. The goal of this Training Program in Biostatistics is to prepare a new generation of biostatisticians who will work side-by-side with biomedical investigators in modern cancer research. Our program aims to provide trainees with Rigorous training in statistics and probability; Practical experience in basic and clinical cancer research; and Training in biological aspects of cancer and medical research ethics. Students in this program follow the standard course of study expected of Ph.D. students in the Department of Statistics at Rice, with additional coursework in biostatistics, biology, and ethics, as well as special seminars and workshops at both institutions. With faculty expertise in Bayesian methods, decision theory, cancer clinical trials, cancer screening, survival analysis, statistical genetics, genomics, bioinformatics, and statistical computing, trainees will receive a broad background in biostatistics necessary for modern cancer research. Summer internships and laboratory rotations provide practical experience in the student's training. Relevance: Combining the educational resources available at Rice University and UTMDACC with practical experience will enable trainees upon completion to make fundamental contributions to cancer research working alongside biomedical investigators. Such close collaboration will lead to more efficient study designs and data analysis, allowing translation of therapeutic theories to clinical application more quickly.