ORWH: SCOR on Sex and Gender Factors Affecting Women's Health

描述（由申请人提供）：在过去的四年中，南卡罗来纳州医科大学（MUSC）关于影响女性健康的性和性别因素的专业研究中心（SCOR）一直作为一个富有成效的跨学科研究中心，专注于女性物质使用障碍的治疗和复发。当MUSC SCOR于2002年成立时，它填补了一个重要的空白。虽然MUSC在物质使用障碍领域的跨学科转化研究方面具有显著的深度和实力，但没有针对性别的重点。此外，MUSC SCOR是在MUSC校园开展的第一个妇女健康研究倡议。SCOR调查人员的积极，校园范围内的合作，与SCOR试点项目计划相结合，鼓励和影响了基于性别的研究校园范围。在延长期内，我们建议将我们的科学项目更紧密地联系起来，并跟进上一个资助期的有趣发现。每个核心研究项目都将涉及调查药物滥用复吸、渴望和/或复发以及治疗影响方面性别差异的生物学基础。该中心的总体目标将不仅侧重于支持和最大限度地发挥核心和试点研究项目的转化科学合作，而且还将继续促进整个MUSC校园内基于性别的研究的增长。MUSC SCOR 6-10年的具体目标是： 具体目标1：继续完善，多学科，研究的重点是在MUSC物质使用障碍的性别相关问题的转化计划。 具体目标#2：通过行政核心提供共同资源，协助调查人员提高效率，最大限度地提高科学严谨性和生产力，并收集试点数据。 具体目标#3：鼓励和支持整个MUSC校园基于性别的研究的增长。 具体目标#4：吸引和指导年轻的研究人员和新的教师在研究领域，特别是面向病人的研究，在妇女的健康问题。 具体目标5：为妇女健康研究提供区域教育和培训资源。 通过P50资助机制的中心资助使我们能够1）在校园内塑造独特的身份，为性别特定研究的重要性带来能量和可见度，2）汇集机构和科学领导，形成一个单一的运营单位，3）建立关键的基础设施支持，以实现资源的有效运营，整合和稳定，4）联合一批高级调查员，将他们的科学专门知识和研究技能结合起来，推动药物滥用领域针对性别的研究，5）吸引和培训针对性别的研究方面的新的和初级调查员，6）通过试点项目资助，支持发展和测试创新想法，以及7）为未来对基于性别的研究感兴趣的基础和临床研究人员提供令人印象深刻的支持性培训环境。 下一个资助期将使我们能够在这些成就的基础上，利用创新技术将我们的研究计划扩展到新的领域，加强我们的推广和传播工作，并通过试点核心吸引新的研究人员。我们的SCOR，与一个真正的跨学科的重点在物质使用障碍的性别问题，是一个现成的资源，为跨ORWH中心合作，因此，是一个资产ORWH计划。

DESCRIPTION (provided by applicant): Over the last four years, the Medical University of South Carolina's (MUSC) Specialized Center of Research (SCOR) on Sex and Gender Factors Affecting Women's Health has functioned as a productive interdisciplinary research center focused on treatment and relapse in substance use disorders in women. When the MUSC SCOR was established in 2002, it filled an important gap. While MUSC had significant depth and strength in translational, interdisciplinary research in the area of substance use disorders, there was no gender-specific focus. Furthermore, the MUSC SCOR was the first women's health research initiative to be undertaken on the MUSC campus. The active, campus-wide collaborations of SCOR investigators, combined with the SCOR pilot project program have encouraged and impacted gender-based research campus-wide. During the renewal period, we propose to more closely link our scientific projects and follow up on intriguing findings from the previous funding period. Each core research project will involve the investigation of the biological basis of sex differences in drug abuse reinstatement, craving and/or relapse, and treatment implications. The overarching goals of the center will focus not only on supporting and maximizing the translational scientific collaborations of the core and pilot research projects, but also on continuing to catalyze the growth of gender-based research throughout the MUSC campus. The Specific Aims for the years 6-10 of the MUSC SCOR are: Specific Aim #1: To continue the well-established, multi-disciplinary, translational program of research focused on gender-related issues in substance use disorders at MUSC. Specific Aim #2: To provide common resources through the Administrative Core to assist investigators in increasing efficiency, maximizing scientific rigor and productivity, and collecting pilot data. Specific Aim #3: To encourage and support the growth of gender-based research throughout the MUSC campus. Specific Aim #4: To attract and mentor young investigators and new faculty in the area of research, particularly patient-oriented research, in women's health issues. Specific Aim #5: To provide a regional education and training resource for research in women's health research. Center funding through the P50 funding mechanism has allowed us to 1) carve out a unique identity on campus, bringing energy and visibility to the importance of gender-specific research, 2) bring together institutional and scientific leadership to form a single operational unit, 3) establish critical infrastructure support to allow for efficient operations, integration, and stability of resources, 4) coalesce a group of senior investigators to integrate their scientific expertise and research skills and advance gender-specific research in the substance abuse area, 5) attract and train new and junior investigators in gender-specific research, 6) support the development and testing of innovative ideas through pilot project funding, and 7) provide an impressive and supportive training environment for future basic and clinical researchers interested in gender based research. The next funding period will allow us to build on these accomplishments, expand our research program into new areas utilizing innovative techniques, enhance our outreach and dissemination efforts, and attract new investigators through the Pilot Core. Our SCOR, with a truly interdisciplinary focus on gender issues in substance use disorders, is a ready resource for inter-ORWH Center collaborations and, as such, is an asset to the ORWH program.