CORE--BIOSTATISTICS AND COMPUTATIONAL BIOLOGY

描述（由申请人提供）：生物统计学和 计算生物学（BCB）研究团队将参与CFAR研究工作， 在新项目的开发阶段和准备赠款提案期间提供实验设计和数据分析咨询，并与研究人员合作研究信息学和数学/统计建模的创新方法。支持的领域将包括临床生物统计学和计算生物学，包括基因表达和核酸和蛋白质序列分析的各个方面。在与杜克大学计算免疫学实验室的合作中，BCB核心还将支持病毒和免疫动力学的方法学开发和数学建模。将以两种方式与CFAR调查员进行互动。在第一种情况下，新的创新项目将被视为合作努力，不向客户收取费用。预计BCB将作为这项新工作产生的赠款和合同的合作者获得报酬。此外，巴塞尔公约协调机构可能有机会提交有关方法学工作的申请。在第二种模式下，正在进行的统计和/或计算生物学工作资助项目以及行业赞助的项目可以签订合同， 与BCB合作BCB核心致力于建立和保持与CFAR调查员和其他核心的便捷沟通。BCB主任，托马斯博士B。开普勒在免疫学（以及杜克免疫学系的二级任命）以及计算生物学和统计学方面具有专业知识，这是他的主要研究领域。核心小组将接受培训，以了解科学和医学及其表达语言。

DESCRIPTION (provided by applicant): The primary responsibilities of the Biostatistics and Computational Biology (BCB) research team will be to participate in the CFAR research effort by supplying experimental design and data-analytical consulting during the developmental stages of new projects and in the preparation of grant proposals and to work with investigators on innovative approaches to informatics and mathematical/statistical modeling. The areas supported will include clinical biostatistics and computational biology, including gene expression and all aspects of nucleic acid and protein sequence analysis. In collaboration with Duke University Laboratory of Computational Immunology, the BCB core will also support methodological development and mathematical modeling of viral and immune dynamics. There will be two modes of interaction with the CFAR investigators. Under the first, new innovative projects will be treated as collaborative endeavors with no charge-back to the client. The expectation is that compensation will accrue to the BCB as collaborators on grants and contracts arising from this new work. Furthermore, the BCB may gain the opportunity to submit applications for related methodological work. Under the second model, ongoing projects with funding for statistical and/or computational biological work as well as industry-sponsored projects can contract with the BCB on a for-fee basis. The BCB core is devoted to the establishment and maintenance of easy communication with the CFAR investigators and the other cores. The BCB director, Dr. Thomas B. Kepler, has expertise in immunology (and a secondary appointment in the Duke Department of Immunology) as well as computational biology and statistics, which are his primary research fields. The core group will be trained to understand the science and medicine and the language in which they are expressed.