Transition Metal Catalysed Oxidation of Olefins: Application to the Synthesis of Heterocycles via Arrays

有机化学是研究碳的化学。通过碳与氮和氧的化合物，它构成了所有生物的基础，如果我们要理解和控制生物过程，了解碳基化合物相互作用的方式是至关重要的。这一点在医药领域最为重要，医药领域为人类的健康和福祉作出了重大贡献。药物发现是由有机化学家推动的，他们制造新的有机化合物来探索它们的性质和与生物学的相互作用。有机化合物还有许多其他用途，如农用化学品的关键成分、聚合物、人工酶、平板显示器、太阳能电池、光学开关和塑料电子产品。因此，化学工业不断需要新的有机结构和制造有机化合物的新工具。在这种背景下，开发新的反应和新的方法来制造大量潜在的候选药物对于将有机合成和药物研究发展成为一个安全、高效和环保的企业至关重要。这里所描述的新化学围绕着有效地大量制造芳香族化合物的方法展开。芳香族化合物是一种非常普遍、有用和广泛的化合物，是上述有机化学所有用途的核心。我们的目标是探索和优化一种控制芳香族化合物形成的新程序，并将其转化为一种能够快速生成大量化合物（集合或库）的过程。上述所有杰出的科学都可以在培养一名博士后研究人员的背景下进行。这是一个严谨的过程，涉及学术界和工业界，理论和实践。最终的结果是培养出一名训练有素、非常适合就业的研究人员，他对化学的最新发展以及化学工业面临的独特挑战有独特的看法。

Organic chemistry is the study of the chemistry of carbon. Through the compounds that carbon makes with nitrogen and oxygen, it forms the basis of all living things and understanding the way in which carbon based compounds interact with each other is of paramount importance if we are to understand and control biological processes. No-where is this more important than in the field of pharmaceuticals, which has made a substantial contribution to the health and well-being of mankind. Drug discovery is driven by organic chemists, who make novel organic compounds to explore their properties and interaction with biology. There are many other uses of organic compounds such as as key components of agrochemicals, polymers, artificial enzymes, flat panel displays, solar cells, optical switches, and plastic electronics. Consequently, chemical industry has a constant need for new organic structures and for new tools for making organic compounds. Within this context, the development of new reactions and new ways of making large numbers of potential drug candidates is vital to develop organic synthesis and pharmaceutical research into a safe, efficient and environmentally friendly enterprise. The new chemistry described here centres around ways of making aromatic compounds efficiently and in large numbers. Aromatic compounds are a very general, useful and broad class of compound and are central to all of the uses of organic chemistry mentioned above.We aim to explore and optimise a new procedure for controlling the formation of aromatic compounds, and will turn it into a process that is able to make significant numbers of compounds (collections or libraries) rapidly.All of the outstanding science descibed above can be conducted in the context of training one postdoctoral researcher. This is a rigorous process that involves both academia and industry, and both theory and practice. The end result is a highly trained, and eminently employable, researcher who has a unique perspective on the latest developments in chemistry together with the unique challenges faced by chemical industry.