THE ROLE OF NEUREGULIN AND ITS RECEPTOR, ERBB4, IN CONDITIONED FEAR LEARNING
THE ROLE OF NEUREGULIN AND ITS RECEPTOR, ERBB4, IN CONDITIONED FEAR LEARNING
批准号:
7562620
负责人:
Kerry J Ressler
金额:
$3.16万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2007
资助国家:
美国
项目状态:
已结题
起止时间:
2007-05-01 至 2008-04-30
关键词:
Computer Retrieval of Information on Scientific Projects DatabaseDominant-Negative MutationErbB4 geneFundingGrantInstitutionLearningLigandsMediationNeuregulinsReportingResearchResearch PersonnelResourcesRoleSourceSubfamily lentivirinaeTestingTransgenic MiceUnited States National Institutes of Healthconditioned fearnovel strategiesreceptorvirus Cre recombinase
中文摘要
这个子项目是许多研究子项目中的一个
由NIH/NCRR资助的中心赠款提供的资源。子项目和
研究者(PI)可能从另一个NIH来源获得了主要资金,
因此可在其他CRISP条目中表示。所列机构为
研究中心,而研究中心不一定是研究者所在的机构。
该建议结合了新的方法来研究ErbB 4受体及其配体neuregulin在条件性恐惧学习中的作用。
本报告期内的进展包括优化和测试显性阴性ErbB 4表达慢病毒,以及与“floxed”neuregulin转基因小鼠联合使用的cre重组酶病毒。
英文摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
This proposal combines novel approaches to studying the role of ErbB4 receptor and its ligand, neuregulin, in the mediation of conditioned fear learning.
Progress during this reporting period includes optimization and testing of a dominant-negative ErbB4 expressing lentivirus, and a cre-recombinase virus to use in combination with 'floxed' neuregulin transgenic mouse.
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会议论文
AMYGDALA VS HIPPOCAMPAL BDNF FUNCTION WITH MOLECULAR GENETIC TECHNIQUES
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批准号:7562621
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项目类别:
-
资助金额:$3.16万
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财政年份:2007
-
负责人:Kerry J Ressler
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依托单位:
GENETIC AND TRAUMA-RELATED RISK FACTORS FOR PTSD
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批准号:7562648
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项目类别:
-
资助金额:$2.37万
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财政年份:2007
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负责人:Kerry J Ressler
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依托单位:
MOLECULAR REGULATION OF GABAA RECEPTORS IN THE AMYGDALA
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批准号:7562649
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项目类别:
-
资助金额:$2.37万
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财政年份:2007
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负责人:Kerry J Ressler
-
依托单位:
SYNAPTIC PLASTICITY AND EXTINCTION OF FEAR
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批准号:7562667
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项目类别:
-
资助金额:$2.37万
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财政年份:2007
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负责人:Kerry J Ressler
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依托单位:
FEAR LEARNING IN MICE AND DISORDERS OF FEAR IN HUMANS
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批准号:7562647
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项目类别:
-
资助金额:$3.16万
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财政年份:2007
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负责人:Kerry J Ressler
-
依托单位:
EXAMINATION OF ALLOSTERIC SITE OF SEROTONIN TRANSPORTER USING TRANSGENIC MICE
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批准号:7562646
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项目类别:
-
资助金额:$2.37万
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财政年份:2007
-
负责人:Kerry J Ressler
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依托单位:
ROLE OF BDNF AND TRKB IN CONDITIONED DEFEAT
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批准号:7349232
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项目类别:
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资助金额:$4.01万
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财政年份:2006
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负责人:Kerry J Ressler
-
依托单位:
Molecular Regulation of GABAalpha Function in Amygdala
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批准号:7276612
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项目类别:
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资助金额:$36.92万
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财政年份:2006
-
负责人:Kerry J Ressler
-
依托单位:
Molecular Regulation of GABA(A) Receptor Function in Amygdala
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批准号:7141576
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项目类别:
-
资助金额:$37.09万
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财政年份:2006
-
负责人:Kerry J Ressler
-
依托单位:
GENETICS AND TRAUMA RELATED RISK FACTORS FOR PTSD
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批准号:7603625
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项目类别:
-
资助金额:$2.59万
-
财政年份:2006
-
负责人:Kerry J Ressler
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依托单位:
MOLECULAR NEUROBIOLOGY OF FEAR IN MAMMALS
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批准号:7349188
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项目类别:
-
资助金额:$4.01万
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财政年份:2006
-
负责人:Kerry J Ressler
-
依托单位:
AMYGDALA VS HIPPOCAMPAL BDNF FUNCTION WITH MOLECULAR GENETIC TECHNIQUES
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批准号:7349287
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项目类别:
-
资助金额:$4.01万
-
财政年份:2006
-
负责人:Kerry J Ressler
-
依托单位:
THE ROLE OF NEUREGULIN AND ITS RECEPTOR, ERBB4, IN CONDITIONED FEAR LEARNING
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批准号:7349286
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项目类别:
-
资助金额:$4.01万
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财政年份:2006
-
负责人:Kerry J Ressler
-
依托单位:
Genetic and Trauma-Related Risk Factors for PTSD
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批准号:7283764
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项目类别:
-
资助金额:$54.51万
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财政年份:2005
-
负责人:Kerry J Ressler
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依托单位:
MOLECULAR NEUROBIOLOGY OF FEAR IN MAMMALS
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批准号:7165933
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项目类别:
-
资助金额:$2.1万
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财政年份:2005
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负责人:Kerry J Ressler
-
依托单位:
ROLE OF BDNF AND TRKB IN CONDITIONED DEFEAT
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批准号:7165985
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项目类别:
-
资助金额:$3.08万
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财政年份:2005
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负责人:Kerry J Ressler
-
依托单位:
Genetic and Trauma-Related Risk Factors for PTSD
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批准号:6970040
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项目类别:
-
资助金额:$54.53万
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财政年份:2005
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负责人:Kerry J Ressler
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依托单位:
DEVELOPMENT OF VIRAL VECTOR FOR GENE DELIVERY & NEURAL TRACT TRACING
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批准号:7165953
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项目类别:
-
资助金额:$3.08万
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财政年份:2005
-
负责人:Kerry J Ressler
-
依托单位:
Genetic and Trauma-Related Risk Factors for PTSD
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批准号:7104199
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项目类别:
-
资助金额:$54.49万
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财政年份:2005
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负责人:Kerry J Ressler
-
依托单位:
RODENT MODEL OF PTSD: FEAR CONDITIONING
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批准号:6971041
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项目类别:
-
资助金额:$3.44万
-
财政年份:2004
-
负责人:Kerry J Ressler
-
依托单位:
海外基金