Data Management and Biostatics Core

这是一个修订后的数据管理和生物统计核心D提案，是大学的一部分。 宾夕法尼亚医学院（PENN）的国家神经病学研究所的修订申请 疾病和中风（NINDS）Morris K. Udall Parkinson's Disease Research Center of Excellence（Udall） 中）。它建议建立一个数据管理和生物统计核心（核心D）， Udall中心内的核心和项目1-4，用于数据管理、中心数据库、统计和 计算机相关的工作。这些服务包括：（a）为数据表格/调查表提供所需支助 设计和开发，数据库开发和管理，数据输入，数据库审计跟踪， 数据库安全、数据库备份和严格的数据质量控制程序，（B）提供计算 和规划支持所有的PENN Udall中心的活动，包括实施和 整合数据管理和研究所需的硬件和软件升级， 对Udall中心的计算系统进行异地存档备份，并支持PENN Udall 中心网站，（c）研究设计的开发，包括进行样本量和把握度计算， 和随机化方案，（d）对PENN Udall中心数据进行分析， （e）促进有效的工作关系 宾夕法尼亚大学尤德尔中心和帕金森病数据组织中心（PD-DOC）之间。因此，在本发明中， 核心D将发挥重要和显著的作用，对研究的进展和开展工作至关重要。 在PENN Udall中心的研究，它将促进PENN Udall之间的协作互动 中心和其他尤德尔中心通过密切和有效的工作关系与PD-DOC。

This is a revised Data Management and Biostatistics Core D proposal which is part of the University of Pennsylvania School of Medicine (PENN)'s revised application for a National Institute of Neurological Disorders and Stroke (NINDS) Morris K. Udall Parkinson's Disease Research Center of Excellence (Udall Center). It proposes the establishment of a Data Management and Biostatistics Core (Core D) to support all Cores and Projects 1-4 within the Udall Center for data management, the Center database, statistical, and computing related work. These services include: (a) providing needed support for data form/questionnaire design and development, database development and management, data entry, database audit trail, database security, database backup, and stringent data quality control procedures, (b) providing computing and programming support for all of the PENN Udall Center activities, including implementation and integration of hardware and software upgrades necessary for data management and research, routine and archival off-site backup of computing systems central to the Udall Center, and support of the PENN Udall Center website, (c) development of study design, including performing sample size and power calculations, and randomization schemes, (d) performing analyses of PENN Udall Center data and the development of new statistical methodology where needed for data analysis, (e) promoting an effective working relationship between the PENN Udall Center and the Parkinson's Disease Data Organizing Center (PD-DOC). Thus, Core D will play an important and significant role that is critical to the progress of research and the conduct of studies in the PENN Udall Center, and it will foster collaborative interactions between the PENN Udall Center and other Udall Centers through a close and effective working relationship with the PD-DOC.