GASTRIC PLICATION FOR GERD AND GASTROPLASTY FOR OBESITY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 胃食道反流病(GERD)影响着全球数百万人。在随机选择的成年人群中，胃灼热的患病率约为20%。据估计，美国大约三分之一的成年人口每月遭受烧心之苦，每周多达10%。在这些患者中，大约7%患有反流性食管炎。在过去的二十年里，由于GERD在西方社会的高患病率、对GERD病理生理学的更好理解、新的有效的抗分泌性药物治疗、微创手术的出现和新的经口、经口、内窥镜治疗的出现，GERD的治疗得到了越来越多的关注。以上述方式改变胃食道屏障以防止胃酸反流的门诊内窥镜手术将吸引患者和医生。本研究将对腔内胃折叠术进行研究。 肥胖被定义为BMI 30，据估计约有17亿人患有肥胖症，其中超重成年人的比例在美国最高。我们打算通过一种通过口腔进行的手术达到类似的结果，该手术产生一个受限的胃袋或胃成形术，但具有最小的侵入性和最大的患者满意度。计划中的动物试验将有助于确定该手术的有效性和安全性。对于肥胖组，终点是观察胃粘膜补片切除后胃成形线的安全性和持久性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Gastroesophageal reflux disease (GERD) affects millions of people worldwide. The prevalence of heartburn in a randomly selected adult population is approximately 20%. It is estimated that approximately one third of the adult population in the United States suffers from heartburn on a monthly basis and as many as 10% weekly. Of these, approximately 7% have reflux esophagitis. The management of GERD has gained increasing attention during the past two decades due to a high prevalence in Western societies, a better understanding of the pathophysiology, new potent anti-secretory drug therapies, the advent of minimally invasive surgery and new transoral, presentation through the mouth, endoscopic therapies. An outpatient endoscopic procedure that would alter the stomach esophageal barrier in the above described ways to prevent acid reflux would be appealing to patients and physicians alike. In this study, endoluminal gastroplication procedure will be studied. Obesity, defined as a BMI 30, is estimated to encompass about 1.7 billion individuals and the percentage of overweight adults is highest in the United States. We intend to achieve similar results with a procedure performed through the mouth that creates a restricted stomach pouch or gastroplasty, but with minimal invasiveness and maximal patient satisfaction. The planned animal trial will assist in determining the efficacy and safety of the procedure.For the obesity group end-points are to observe the safety and durability of the gastroplasty lines after mucosal patch excision.