BONE GRAFT SUBSTITUTE FOR INTER-BODY SPINAL FUSION

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 脊椎疾病是当今社会最常见、最昂贵的疾病之一。仅在美国，每年就有300亿美元用于腰痛的外科治疗。每年大约有40万例这样的手术。在2008年，黄金标准仍然是使用患者自己骨盆的松质骨(即所谓的自体髂骨植骨)进行脊柱融合。获得后者往往伴随着持续的疼痛(高达30%的患者)，但也会出现更严重的并发症，如血管撕裂、神经损伤、骨盆或髋部骨折等。使用与骨一样形成骨融合的人造材料，将避免从骨盆取出骨。一种新的人工材料将在狒狒实验中进行临床适用性测试。 在6个月的存活期内，植入物间隔物有望骨性融合，从而在相邻的两个椎体之间形成稳定的桥梁(这一过程被称为脊柱融合)。这种人造材料经过测试，至少达到了与天然骨一样的愈合效果，甚至可能更好。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Spine ailments are amongst the most common and costly illnesses of today's societies. In the US alone, 30 billion dollars are spent annually for the surgical treatment of low back pain. About 400,000 such surgeries are performed every year. The gold standard, in 2008, still is to perform a spine fusion, using spongy bone of the patient's own pelvis (so called autologous iliac crest bone graft). To obtain the latter is often associated with prolonged pain (up to 30% of the patients), but also more serious complications such as vessel lacerations, neural damage, pelvic or hip fracture, etc. To use an artificial material that is forming a bone fusion just as bone does, would avoid taking bone from the pelvis. A new artificial material shall be tested in a baboon experiment for its clinical suitability. During a six month survival period the implant spacer is expected to bony integrate and thus form a stable bridge between the two adjacent vertebral bodies (this process is called a spine fusion). The artificial material is tested for achieving at least equal or possibly even better healing results compared to natural bone.