HDL AND SOF

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 HDL是将胆固醇转运回肝脏进行处置的重要载体。血清不透明因子（SOF）是链球菌产生的一种物质，靶向HDL并选择性地从HDL颗粒中去除脂质，产生大的富含胆固醇的微乳液（CERM）。SOF可能在临床上有用，在生产更活跃的HDL颗粒以及更有效地将胆固醇转移到肝脏。在这个项目中，我们正在研究HDL与SOF的相互作用，并从结构上表征脱脂过程。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. HDL are important vehicles for transporting cholesterol back to the liver for disposal. Serum opacity factor (SOF), a substance produced by strep bacteria, targets HDL and selectively removes lipids from the HDL particles, producing large cholesterol rich microemulsions (CERMs). SOF may be clinically useful, in production of more active HDL particles as well as moving cholesterol more efficiently to the liver. In this project we are studying the interaction of HDL with SOF and structurally characterizing the delipidation process.