Shared Resources-Biomedical Informatics

生物医学信息学共享资源建立在耶鲁中心之间的长期合作基础上 医学信息学(YCMI)、YCC临床研究服务(CRS)和耶鲁大学 病理信息学小组。共享资源成立于1996年，最初的目标是开发 一个多学科数据库，用于收集、存储、整理和帮助分析临床试验和临床数据 研究研究，一个现在称为试验/数据库的系统。在过去的十年中，共享资源的活动 已经显著扩大了。 Trial/DB现在运行良好，正在用于所有YCC调查员发起的试验，并正在 不断扩充和完善，以满足YCC研究人员的需求。 TrialTracker系统是为了跟踪有关试验的行政信息而建立的，现在所有人都使用它 YCC试验。 目前的一个主要项目是在耶鲁肿瘤的基础上开发一个癌症数据库(CADR) 登记制度。干部的发展是朝着发展更广泛的体制迈出的一步 耶鲁大学的临床数据库，将癌症作为试点领域。 另一项支持YCC生物科学的倡议涉及维护和完善两个数据库和相关的 软件工具、Cruella(用于组织阵列研究)和GeneCube(用于DMA微阵列研究)。 共享资源还参与了一些与国家caBIG倡议有关的活动。 其他活动包括1)逐步将试验/数据库和最终的CADR与其他 YCC使用的信息系统，以及2)协调YCC的活动与数据密集型 耶鲁大学正在开发基因组/蛋白质组信息学和临床成像基础设施。 癌症中心成员对该设施的总体使用率为94.6%(88.8%为同行评议)。共享的 资源被17个YCC用户使用，基于8个YCC项目中的7个。

The Biomedical Informatics Shared Resource builds upon a longstanding collaboration among the Yale Center for Medical Informatics (YCMI), the YCC Clinical Research Service (CRS), and the Yale Department of Pathology Informatics Group. The Shared Resource was inaugurated in 1996 with the initial goal of developing a multi-disciplinary database to collect, store, curate, and help analyze data .for clinical trials and clinical research studies, a system now called Trial/DB. Over the past decade, the activities of the Shared Resource have significantly broadened. Trial/DB is now robustly operational and is being used for all YCC investigator initiated trials, and is continuing to be augmented and refined to meet the needs of YCC researchers. The TrialTracker system was built to track administrative informatics about trials, and is now used for all YCC trials. One major current project is developing a Cancer Data Repository (CaDR) building on the Yale Tumor Registry system. The development of the CaDR is a step toward developing a much broader institutional clinical data repository at Yale, using cancer as a pilot domain. Another initiative, in support of YCC bioscience, involves maintaining and refining two databases and related software tools, Cruella (for tissue array research) and GeneCube (for DMA microarray research). The Shared Resource is also involved in a number of activities related to the national caBIG initiative. Additional activities include 1) incrementally integrating Trial/DB, and ultimately the CaDR, with other information systems used by the YCC, and 2) coordinating YCC's activities with data-intensive genomic/proteomic informatics and clinical imaging infrastructure being developed at Yale. Overall usage of this facility by Cancer Center members is 94.6% (88.8% Peer-reviewed). The Shared Resource is utilized by 17 YCC users, based in 7 of the 8 YCC programs.