Research Training - Genetics of Substance Abuse

描述（由申请人提供）： 这项提案正在寻求通过机构培训赠款继续支持一项培训方案，培训将从事研究职业的博士前和博士后研究员，重点是研究遗传对药物滥用的影响。IBG教师是杰出的和活跃的研究和IBG科学家积极追求的遗传对药物滥用的影响的研究超过40年。与药物滥用有关的主要研究项目目前正在人类和动物行为遗传学方面取得进展。生物统计学、统计学和数量遗传学技术的应用以及数量性状基因座方法的发展使得能够对调控复杂性状的基因进行定位和鉴定。从这些分析中得到的信息，沿着神经化学、神经药理学、神经生理学和分子遗传学的研究，将提供对与行为相关的基因功能的理解。人类和动物行为遗传学方面的主要研究项目正在进行中，包括大规模的国家合作研究，积累了DNA储存库和丰富的表型数据集，可用于药物滥用研究。设施可用于基因型测定，包括全基因组测定，基因功能和表达研究，以及行为，生物化学和神经生理学研究。申请的资金用于在总共5年的时间内支持4名博士前和2名博士后学员。博士预科生获得合作学术单位的博士学位和行为遗传学证书。培训计划的学术要求包括行为遗传学，定量和生物统计遗传学，理论和基于计算机的统计学，分子遗传学，生物信息学和基因组学，负责任的研究行为以及行为和临床表型课程的培训。附加要求根据学位授予学术单位而有所不同。研究经验是培训的一个组成部分。博士后学员也追求一个正式的计划，强调个人研究以及在分子和定量行为遗传学的能力。在心理健康的研究生涯准备的其他活动包括：学生和/或技术人员的监督，研讨会演讲者的主持，客座演讲，每周杂志俱乐部，并在研究的负责任的行为当然强制出席。 这项建议是为了培训科学家，使他们能够大大有助于我们了解遗传因素对药物滥用的影响。这种认识将导致采取新的办法来预防和减轻药物滥用。

DESCRIPTION (provided by applicant): This proposal is seeking continued support, via an institutional training grant, for a training program for pre- and postdoctoral fellows who will pursue research careers that focus on the study of genetic influences on substance abuse. The IBGfaculty is distinguished and active in research and IBG scientists have actively pursued studies of genetic influences on substance abuse for over 40 years. Major substance abuse-related research projects are now in progress in both human and animal behavior genetics. The application of biometrical, statistical, and quantitative genetic techniques and the development of quantitative trait loci methods allow the mapping and identification of genes that regulate complex traits. Information from such analyses, along with neurochemical, neuropharmacological, neurophysiological, and molecular genetic studies, will provide an understanding of gene function related to behavior. Major research projects are now in progress in both human and animal behavior genetics, including large scale national collaborative studies amassing DNA repositories and rich phenotypic data sets available for studies of substance abuse. Facilities are available for genotype assay, including genome-wide assays,gene function and expression studies, and behavioral, biochemical, and neurophysiological studies. Funds are requested to support 4 predoctoral and 2 postdoctoral trainees over a total period of 5 years. Predoctoral trainees receive doctorate degrees from a cooperating academic unit and certification in behavior genetics. Academic requirements in the training program include training in behavior genetics, quantitative and biometrical genetics, theoretical and computer-based statistics, molecular genetics, bioinformatics and genomics, responsible conduct of research, and courses on behavioral and clinical phenotypes. Additional requirements vary according to the degree granting academic unit. Research experience is an integral part of training. Postdoctoral trainees also pursue a formalized program that emphasizes individual research as well as competence in molecular and quantitative behavior genetics. Other activities in preparation for research careers in mental health include: supervision of students and/or technicians, hosting of seminar speakers, guest lecturing, a weekly journal club, and mandatory attendance in a course on the responsible conduct of research. This proposal is to train scientists who will be able to contribute significantly to our understanding of genetic contributions to the vulnerability to develop substance abuse. This understanding will lead to new approaches to the prevention and alleviation of substance abuse.