Infectious Diseases Training Program

说明(申请人提供)：在预防某些传染病的发生(通过疫苗和公共卫生措施)和治疗某些传染病(通过开发抗菌剂)方面取得了重大进展。然而，传染病仍然是一个重大的全球健康威胁，显然，各国都需要提高我们预防、检测和控制微生物疾病的能力。要实现这一目标，关键是要进行高质量的传染病基础科学研究，培养优秀的传染病研究人才。基础科学研究对于阐明微生物病原体致病的机制，阐明宿主免疫系统成功防御微生物病原体的机制，以及确定预防和/或治疗感染性病原体的新策略是必要的。位于达拉斯的德克萨斯大学西南医学中心拥有一批从事传染病基础科学研究的优秀高级研究人员，因此，它是培养对传染病感兴趣的博士科学家和对传染病实验室研究职业感兴趣的医生的理想条件。我们建议的主要目标是为博士和医学博士后研究员提供出色的传染病实验室研究培训，以便这些人可以发展成为成功的独立研究人员，他们将成为该领域的未来领导者。这将通过以下方式实现：向在宿主-病原体相互作用的不同方面进行最新研究的杰出导师提供重点培训，通过提供1)高度刺激的多学科研究环境，2)来自培训资助教师的密切监督和支持，以及3)在研究和职业发展的实际方面(例如，伦理学、生物统计学、手稿和赠款写作、专利和专利问题)以及在不同科学领域的教学培训(例如，宿主-病原体相互作用、免疫学、细胞生物学、分子生物学、病毒学)，这将丰富他们的研究培训经验，提高他们的研究质量。与德克萨斯大学西南分校卓越的科学环境一起，这种多方面的方法来培训传染病研究方面的博士后研究员，将培养出一批优秀的年轻研究人员，他们具有为全球预防和/或治疗传染病作出宝贵贡献的强大潜力。

DESCRIPTION (provided by applicant): Major advances have been made in preventing the occurrence of some infectious diseases (through vaccines and public health measures) and in the treatment of some infectious diseases (through the development of antimicrobial agents). However, infectious diseases remain a major global health threat, and it is clear that there is a significant national need to improve our ability to prevent, detect, and control microbial diseases. To accomplish this goal, it is essential that high quality basic science research be performed in infectious diseases and that our nation trains outstanding people to perform such research. Basic science research is necessary to elucidate the mechanisms by which microbial pathogens cause disease, to elucidate the mechanisms by which the host immune system can successfully defend against microbial pathogens, and to define novel strategies to prevent and/or treat infectious pathogens. The University of Texas Southwestern Medical Center at Dallas has an outstanding group of senior investigators performing basic science research in Infectious Diseases, and is therefore, ideally positioned to train both Ph.D. scientists interested in Infectious Diseases and physicians who are interested in laboratory-oriented research careers in Infectious Diseases. The major goal of our proposal is to provide outstanding laboratory research training in Infectious Diseases to Ph.D. and M.D. postdoctoral fellows so that these individuals may develop into successful independent investigators who will become future leaders in the field. This will be accomplished by providing focused training with outstanding preceptors who conduct state-of-the-art research in different aspects of host-pathogen interactions, by providing 1) a highly stimulating multidisciplinary environment for research, 2) close supervision and support from training grant faculty, and 3) didactic training in both practical aspects of research and career development (e.g., ethics, biostatistics, manuscript and grant writing, patent and proprietary issues) as well as didactic training in diverse areas of science (e.g., current topics at the interface of host-pathogen interactions, immunology, cell biology, molecular biology, virology) that will enrich their research training experience and enhance the quality of their research. Together with the outstanding scientific environment at UT Southwestern, this multi-faceted approach to training post-doctoral fellows in Infectious Diseases research will produce an outstanding group of young investigators with strong potential to make valuable contributions to the global prevention and/or treatment of infectious diseases.