Training Program in Hematology

描述(由申请人提供)：血液学学科仍然是将免疫学、分子生物学和细胞生物学的基本科学发现转化为人类有希望的新疗法的典范。为了最大限度地将新生的科学知识转化为临床血液学知识，我们需要留住一批才华横溢、训练有素的内科科学家，他们将在实验室和临床之间进行翻译。为了将基础科学与临床研究完全联系起来，受训者必须在激励和促进研究的环境中接受严格的实验室培训和强有力的指导。不幸的是，在血液学学科方面接受过这种培训的年轻研究人员很少。最近对美国和加拿大成人和儿童血液学/肿瘤学副专科培训项目主任的一项调查发现，接受过学术血液学培训的研究员存在不足(1)。这项研究指出，“少数选择血液学单板资格(100/o)并从事非恶性血液学职业(占成人培训项目毕业生的6%)的受训者受到了关注。”约翰霍普金斯大学的血液科是美国仅存的几个独立的血液学项目之一。因此，拟议的培训计划的目的是为拥有医学博士和/或博士学位的合格个人在血液学领域的研究生涯做好准备。血液学研究培训计划为准备在血液学研究领域全职工作的个人提供跨学科的实验室培训。受训人员在主要研究人员的实验室中从事与良性和恶性血液疾病生物学相关的项目。这些研究项目结合参与课程工作、研究研讨会、期刊俱乐部、实验室会议和出席国家和国际会议，为受训人员提供了作为独立调查人员成功发挥作用所需的基本知识和技能。

DESCRIPTION (provided by applicant): The discipline of Hematology continues to be a model for translating basic scientific discoveries in immunology, molecular biology, and cellular biology into promising new therapies for human beings. To maximize our opportunity to translate nascent scientific knowledge into clinical hematology, we need to perpetuate the pool of gifted and highly trained physician-scientists who will translate between the laboratory and the clinic. To fully link basic science with clinical investigation, a trainee must receive rigorous laboratory training and strong mentoring in a stimulating and nurturing research environment. Unfortunately, there is a shortage of young investigators with such training in the discipline of hematology. A recent survey of directors of adult and pediatric hematology/oncology subspecialty training programs in the United States and Canada found a deficiency in fellows trained in academic Hematology (1). The study stated that, "Concern is raised over the small numbers of trainees who opt for single-board eligibility in Hematology (100/o) and pursue careers in nonmalignant Hematology (<6% of graduates of adult training programs)." The Division of Hematology at Johns Hopkins is one of the few remaining free-standing Hematology Programs in the country. Thus, the purpose ofthe proposed training program is to prepare qualified individuals with an M.D. and/or Ph.D. degree for a research career in the field of Hematology. This program for research training in hematology provides interdisciplinary laboratory training for individuals preparing for full-time careers in hematology research. Trainees work on projects relevant to the biology of benign and malignant blood disorders in the laboratories of leading investigators. These research projects, in conjunction with participation in course-work, research seminars, journal clubs, laboratory meetings, and attendance at National and International meetings, afford trainees the basic knowledge and required skills to function successfully as independent investigators.