New imaging techniques

在x射线领域，我们发明了傅立叶x射线散射成像，并发表了它的物理原理和第一个生物应用演示。我们正在与临床放射学中心的布拉德·伍德博士合作，将这项技术应用到临床数字放射成像单元。美国国立卫生研究院技术转移办公室已经就这项技术提交了临时专利申请。与Argonne国家实验室的Barry Lai博士和他的同事们一起，我们探索了将在ANL建造的高分辨率FSI设备。我们已经开发了去除FSI图像中伪影的方法，并开始为大鼠骨质疏松症研究做准备。RAT研究的具体内容是与供应商签订的建造垂直FSI系统的合同。 在心血管成像方面，我们完成了一个提高单次激发序列颈动脉壁应变成像稳健性的项目，并在正常志愿者和一例中风患者获得了1.5T和3T的数据。研究结果包含在一份即将完成的手稿中。我们总结了开发一种位移编码的脉冲序列以同时在心肌壁进行灌注和应变成像的项目。该项目包括猪方案的验证和急性心肌梗死患者(STEMI)的性能测试。这份手稿已经过审阅，并已提交修订稿。我们目前正在进行第三个项目，以改进扩散成像中的信号处理。

In the x-ray area we have invented Fourier x-ray scattering imaging and published its physical principle and a first demonstration of biological application. We are working with Dr. Brad Wood of Clinical Center Radiology on the implementation of this technology to a clinical digital radiography unit. NIH Office of Technology Transfer has filed a provisional patent application on this technology. With Dr. Barry Lai and his colleagues at Argonne National Laboratory we explored a high resolution FSI device to be constructed at ANL. We have developed methods to remove artifacts in FSI images, and begun preparation for a rat osteoporosis study. Specifically to the rat study is a contract with a vendor to build a vertical FSI system. In the area of cardiovascular imaging, we have finished a project to improve the robustness of carotid artery wall strain imaging with a single-shot sequence and obtained data at both 1.5T and 3T in normal volunteers and in one stroke patient. The results are included in a manuscript near completion. We concluded the project to develop a displacement-encoded pulse sequence for simultaneous perfusion and strain imaging in the myocardial wall. This project included validation in a swine protocol and performance testing in acute myocardial infarction patients (STEMI). The manuscript has been reviewed and a revision has been submitted. We are currently working on a third project to improve signal processing in diffusion imaging.