Analyses Of Data From The Collaborative Perinatal Project

2009年开展和/或发表的工作涉及几个一般领域：1)各种炎症介质的母体血清浓度与随后的妊娠结局2)先兆子痫的危险因素3)维生素D在长期储存中的稳定性4)血清25羟基维生素D与妊娠结局4)出生和早产之间体重指数的变化；5)母体EPHX1基因多态与苯妥英诱发先天畸形的风险。 主题1的结果表明，在流产发生之前，趋化因子ENA-78的水平升高，但IL-8、MIP-1945、MIP-1946、MCP-1和RANTES的水平与这一结果无关。此外，在细胞因子中，促血小板生成素与流产有关。 主题2的结果表明，妊娠晚期母体血清可可碱浓度(巧克力中主要的黄嘌呤生物碱)与先兆子痫的发生无关。妊娠前半期血清可可碱与先兆子痫的风险增加有关。这些结果与之前的发现不同，即脐带血中较高的可可碱与降低先兆子痫的风险有关，母亲摄入巧克力也是如此。 主题3的结果表明，血清25(OH)维生素D水平在储存40年或更长时间后保持稳定。专题4的分析正在进行中。实施病例队列设计，以确定妊娠前半期获得的血清25-OH维生素D水平与先兆子痫和早产之间的关系。 最后，目前正在审查的分析5表明，在怀孕期间服用苯妥英钠(苯妥英)的妇女中，具有与产生更多反应代谢物相关的基因多态的妇女生下具有胎儿海因综合征特征的孩子的风险大约增加一倍。

Work conducted and/or published during 2009 has addressed several general areas: 1) maternal serum concentrations of various inflammatory mediators and subsequent pregnancy outcome 2) risk factors for preeclampsia 3) stability of vitamin D in long-term storage 4) serum 25 Hydroxyvitamin D and pregnancy outcomes 4) change in BMI between births and preterm birth; 5) maternal EPHX1 polymorphisms and risk of phenytoin-induced congenital malformations. Results from topic 1 indicated that elevated levels of the chemokine ENA-78 preceded the occurrence of miscarriage, but that levels of IL-8, MIP-1945;, MIP-1946;, MCP-1 and RANTES were not associated with this outcome. In addition, among cytokines, thrombopoietin was associated with miscarriage. Results from topic 2 indicate that maternal serum theobromine concentration (the main xanthine alkaloid in chocolate) in the third trimester is not associated with the development of preeclampsia. Serum theobromine in the first half of pregnancy was associated with an increased risk of preeclampsia. These results are at variance with previous findings that higher cord blood theobromine is associated with reduced risk of preeclampsia, as is maternal chocolate intake. Results from topic 3 indicate that serum 25 (OH) vitamin D levels are stable after 40 or more years in storage. Topic 4 analysis is ongoing. A case-cohort design was implemented in order to determine the association between serum 25-OH vitamin D levels obtained in the first half of pregnancy and the developement of preeclampsia and preterm birth. Finally, analysis 5, results of which are currently under review demonstrated that among women taking phenytoin (Dilantin) during pregnancy, women who had genetic polymorphisms associated with production of increased amounts of reactive metabolites were at approximately doubled risk of having a child with the characteristic features of fetal hydantoin syndrome.