QTRAP 5500 Triple Quadrupole Mass Spectrometer System

描述(由申请人提供)：本提案要求使用AB Sciex QTRAP 5500三重四极杆质谱仪系统，该系统将用于对人类健康重要的项目，例如：疟疾和癌症新药的开发、头颈部癌症结果和治疗的预测指标、厌氧细菌的新陈代谢、糖耐量受损的病理生理学、药代动力学和终末期肾脏疾病。所要求的文书是一种成熟的、商业上可用的文书，其特点使其非常适合所提议的项目。该仪器将设在一个具有长期经验和强有力的互动与合作的资源设施中。专家人员将负责仪器的操作和维护。行政支助、科学人员和咨询委员会，加上强有力的机构支助，将确保拟议和未来的项目有效利用三重四极杆质谱仪。 公共卫生相关性：所要求的QTRAP 5500三重四极质谱计系统将用于对人类健康重要的项目。这些包括：疟疾和癌症新药的开发，头颈部癌症结果和治疗的预测因素，厌氧细菌的代谢，糖耐量受损的病理生理学，以及终末期肾脏疾病。

DESCRIPTION (provided by applicant): This proposal requests an AB Sciex QTRAP 5500 triple quadrupole mass spectrometer system that will be utilized in projects important to human health, for example: development of new drugs for malaria and cancer, predictors for head and neck cancer outcome and therapy, metabolism of anaerobic bacteria, pathophysiology of impaired glucose tolerance, pharmacokinetics, and end stage renal disease. The requested instrument is an established, commercially available instrument that has features making it ideally suited for the projects proposed. The instrument will be located in a resource facility with longstanding experience and strong interactions and collaborations. Expert personnel will be responsible for operation and maintenance of the instrument. The administrative support, scientific personnel and advisory committee, plus strong institutional support will ensure effective utilization of the triple quadrupole mass spectrometer by the proposed and future projects. PUBLIC HEALTH RELEVANCE: The QTRAP 5500 triple quadrupole mass spectrometer system requested will be utilized in projects important to human health. These include: development of new drugs for malaria and cancer, predictors for head and neck cancer outcome and therapy, metabolism of anaerobic bacteria, pathophysiology of impaired glucose tolerance, and end stage renal disease.