RHESUS SPF COLONY FOR NON AIDS RESEARCH

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 背景：在非人类灵长类研究动物中存在逆转录病毒感染，这使得它们不适合进行一些研究。此外，在研究中使用的非人类灵长类动物中存在B病毒是一个重大的职业安全和健康问题。创建了无特定病原体(SPF)计划，为恒河猴提供SIV、SRV、STLV-1和B病毒的血清阴性。大多数被分配到SPF繁殖计划的动物都在NCRR/OAR艾滋病殖民地，这限制了分配给艾滋病研究计划的动物。这里描述的基础拨款支持的SPF群体允许将SPF动物分配到除艾滋病研究之外的其他地方。方法：一岁的恒河猴与其出生群体中的同龄人一起居住，而病毒筛查在1-3岁进行，然后被转移到更大的繁殖群体中。检测出病毒剂呈阳性的动物将被从SPF计划中删除。一岁的恒河猴目前正被从传统繁育群体中移出，以便纳入SPF计划。结果/讨论：该种群目前有885只动物(267只中国恒河猴和618只印度恒河猴)。2009年，共有48只动物被分配到核心和附属研究人员手中。此外，在繁殖群体中还出现了对动物的背负使用。包括血液、粪便、唾液和骨髓在内的组织被提供给研究人员，以支持他们的研究计划。还收集了行为/观察数据，以支持研究和管理计划。所有对动物的背负式使用都是非侵入性的或微侵入性的，允许动物留在它们的社会群体中，不影响生产。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Background: The presence of retroviral infection in nonhuman primate research animals makes them unsuitable for a number of research studies. In addition, the presence of B-virus in nonhuman primates used in research is a significant occupational safety and health concern. The specific pathogen free (SPF) program was created to provide rhesus monkeys seronegative for SIV, SRV, STLV-1, and B-virus. The majority of the animals assigned to the SPF breeding program are in the NCRR/OAR AIDS colony which limits assignment of animals to AIDS research programs. The base grant supported SPF colony described here allows allocation of SPF animals to other than AIDS studies. Methods: Yearling rhesus are housed with peers from their natal groups while viral screening occurs during years 1-3 and are then moved into larger breeding groups. Animals testing positive for viral agents are removed from the SPF program. Yearling rhesus macaques are currently being removed from the conventional breeding colony for inclusion in the SPF program. Results/Discussion: The colony currently consists of 885 animals (267 Chinese-origin rhesus and 618 Indian-origin rhesus). In 2009, a total of 48 animals were assigned to core and affiliate researchers. In addition, piggybacked use of animals in the breeding colony occurred. Tissues, including blood, feces, saliva, and bone marrow, were provided to investigators to support their research programs. Behavioral/observational data were also collected to support research and management programs. All piggyback use of animals is noninvasive or minimally invasive and allows animals to remain in their social groups with no impact to production.