COOPERATIVE RESEARCH ON INFERTILITY IN PRIMATES (U54)

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 ONPRC的不孕不育和生殖研究专业合作中心(U54)致力于人类不孕不育疾病的原因和治疗，因为它们与神经、性腺和配子缺陷有关。每个研究项目都在翻译研究中使用非人类灵长类动物，其中两个项目包含与女性健康相关的新信息的临床成分。项目一，“普通生活压力对生育力的影响”，调查了与轻度压力(例如，节食、心理社会变化)组合有关的神经内分泌和性腺损害。项目II，“跨突触控制LHRH释放的新机制”继续进行 基因和细胞操作，以评估GABA输入和其他新基因(例如，IAP-1)在神经元通路中控制LHRH神经元和生殖周期中的作用。项目三，“自然和受控卵巢刺激(COS)周期中的血管生成和血管溶解因子”，研究血管生成素(Ang)和内分泌腺(EG)-VEGF在卵泡和黄体中的表达和作用，以及Ang、EG-VEGF和VEGF-A的变化是否会导致卵巢紊乱，如卵巢过度刺激综合征(OHSS)。项目四，“雌性青春期前猴子的雄激素暴露：与多囊卵巢综合征的相关性？”，将确定青春期前雌性恒河猴长期暴露于高水平的睾酮是否会导致神经内分泌轴的变化，使人联想到多囊卵巢综合征(PCOS)。所有项目都试图将基本生殖过程与不孕不育的病因和/或治疗联系起来。这些项目得到了三个核心实验室(辅助生殖技术、成像和形态、分子和细胞生物学)的支持，这些实验室以“开放获取”的形式运作。有关进度报告和出版物，请参阅个别项目。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. ONPRC's Specialized Cooperative Center (U54) in Infertility and Reproduction Research addresses the causes and cures of human infertility disorders as they pertain to neural, gonadal and gamete deficits. Each research project utilizes nonhuman primates in translational research, and two contain clinical components that relate new information to women's health. Project I, "Effect of Common Life Stresses on Fertility" investigates the neuroendocrine and gonadal lesions associated with a combination of mild forms of stress (e.g., dieting, psychosocial changes). Project II, "Novel Mechanisms Underlying the Transsynaptic Control of LHRH Release" continues genetic and cellular manipulations to evaluate the role of GABA input, and other novel genes (e.g., IAP-1) in neuronal pathways, in controlling LHRH neurons and reproductive cyclicity. Project III, "Angiogenic and Angiolytic Factors in Natural and Controlled Ovarian Stimulation (COS) Cycles" examines the expression and action of angiopoietin (Ang) and endocrine gland (EG)-VEGF in the follicle and corpus luteum, and whether alterations in Ang, EG-VEGF, as well as VEGF-A, cause ovarian disorders, such as ovarian hyperstimulation syndrome (OHSS). Project IV, "Androgen Exposure in Female Pre-pubertal Monkeys: Relevance to PCOS?", will determine whether chronic exposure of prepubertal female rhesus monkeys to elevated levels of testosterone causes changes in the neuroendocrine-ovarian axis reminiscent of those observed in polycystic ovarian syndrome (PCOS). All projects attempt to relate basic reproductive processes to the etiology and/or treatment of infertility. These projects are supported by three core (Assisted Reproductive Technologies; Imaging & Morphology; Molecular & Cellular Biology) laboratories operating in an "open access" formulation. See individual projects for progress reports and publications.