TAS::75 0862::TAS STUDIES TO EVALUATE TOXIC AND CARCINOGENIC POTENTIAL OF TEST A

本项目的目标是评估2-羟基-4-甲氧基二苯甲酮（HMB）的慢性毒性和致癌性，膳食暴露。HMB用于防晒霜。2-HMB的慢性毒性和致癌性研究处于活体阶段。这些研究包括围产期接触（妊娠期和哺乳期接触）。人类可能通过环境类似地暴露于这些化合物。围产期接触发生在发育的关键时期，与仅从成年期开始接触相比，可能导致毒性/致癌性的差异。在HMB研究中，大鼠在2年研究前在围产期暴露，而在小鼠中进行标准研究。 关键词：毒性，致癌性，饮食，围产期，2-羟基-4-甲氧基二苯甲酮

The goal of this project is to evaluate the chronic toxicity and carcinogenicity of 2-hydroxy-4-methoxybenzophenone (HMB), following dietary exposures. HMB is used in sunscreens. 2-Year chronic toxicity and carcinogenicity studies of HMB are in the in life phase. These studies include perinatal exposures (exposure during gestation and lactation). Humans are likely to be similarly exposed to these compounds through the environment. Perinatal exposure occurs during critical periods of development and can result in differences in toxicity/carcinogenicity as compared to exposure starting only from adulthood. In the HMB study, rats were exposed perinatally prior to the 2-year study, while standard studies are being conducted in mice. Keywords: toxicity, carcinogenicity, diet, perinatal, 2-hydroxy-4-methoxybenzophenone