REGULATION OF GENE EXPRESSION IN HUMAN BLADDER TISSUE

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 我们正在与Videra博士合作，将人类膀胱癌组织唾液酸化和唾液酸转移酶转录水平的变化联系起来。 这些研究刚刚开始，但先前的数据表明膀胱癌样品中唾液酸化聚糖结构的上调，我们的合作研究集中在确定这些结构是否是由这些转化组织中唾液酸转移酶或唾液酸酶的转录调节产生的。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We are collaborating with Dr. Videra to correlate changes in tissue sialylation and sialyltransferase transcript levels in human bladder cancer. These studies have just been initiated, but prior data indicated an upregulation of sialylated glycan structures in the bladder cancer samples and our collaborative studies are focused on determining if these structures are generated by transcriptional regulation of sialyltransferases or sialidases in these transformed tissues.