RESTORING NORMAL FREQUENCY AND DURATION OF FEMALE SEXUAL BEHAVIOR

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 目的：提高对5-羟色胺相关神经机制调控雌性性反应的认识，为临床治疗女性性功能减退提供更合适的方法。 据估计，43%的女性会受到性功能障碍的影响。目前还没有批准的药物疗法来治疗这种疾病。对雌激素和孕激素激素治疗安全性的担忧促使人们寻求非类固醇药物治疗。5-羟色胺神经系统参与了包括人类和非人类灵长类在内的一系列雌性哺乳动物的性行为调控，但其中涉及的机制尚不清楚。我们已经开发了一个以雌性常见绒猴为对象的模型系统，以证明5-羟色胺类似物8-羟基DPAT会降低女性对男性性行为的接受程度，而另一种类似物氟班丝林则不会。氟班色林还增强了男女之间的积极社交互动，包括美容。非侵入性PET脑成像显示女性神经活动的特定变化与每种5-羟色胺药物的不同行为结果相关。每种药物不同的5-羟色胺受体结合特性开始为神经作用机制和治疗应用提供线索。出版物正在等待发布。 这项研究使用了WNPRC化验服务和动物服务。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To improve our understanding of serotonin-related neural mechanisms regulating female sexual response in marmosets in order to develop more appropriate clinical intervention for sexual hypofunction in women. Sexual dysfunction affects an estimated 43% of women. Currently there are no approved drug therapies for this disorder. Safety concerns about hormonal treatment with estrogens and progestogens motivates the search for non-steroidal pharmoacotherapy. The serotonin neuronal system has been implicated in regulating sexual behavior in a range of female mammals, including humans and nonhuman primates, but the mechanisms involved are not well understood. We have developed a model system with female common marmosets to demonstrate that a serotonin analogue, 8-hydroxyDPAT, diminishes female acceptance of male sexual advances, while another, flibanserin, does not. Flibanserin also enhances positive social interactions between male-female pairs, including grooming. Non-invasive PET brain imaging suggests specific changes in female neural activity associated with the different behavioral outcomes for each serotonin drug. The different serotonin receptor binding properties of each drug are starting to provide clues as to neural mechanisms of action and theraputic application. Publications are pending. This research used WNPRC Assay Services and Animal Services.