POLYCYSTIC OVARY SYNDROME (PCOS) AND FETAL, NEONATAL AND ADULT BIOMARKERS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 目的：探讨反映多囊卵巢综合征(PCOS)胎儿程序化机制的胎儿、新生儿和成人标志物。 该项目继续确定雌性恒河猴胚胎在怀孕早期暴露于雄激素过剩的胎儿和新生儿的后果。目前的结果表明，怀孕的恒河猴母亲服用过量的雄激素而导致的高血糖妊娠可能会导致暴露的雌性婴儿胰岛形态的改变，这可能解释了胰岛素介导的葡萄糖调节的功能改变。这项工作为多囊卵巢综合征的这种非人类灵长类动物模型中的代谢缺陷的胎儿编程提供了额外的直接证据。 本研究使用了WNPRC化验服务、病理学服务和动物服务。 出版物： 雅培·戴维德，杜梅西奇检察官。2009年。成人多囊卵巢。亮点17：13-18。 雅培公司，塔兰塔尔公司，杜梅西奇公司。2009雄激素孕前雌性恒河猴多囊卵巢综合征的胎儿、婴儿、青少年和成年表型。我是J普利马托尔。71：776-784。 首页--期刊主要分类--期刊细介绍--期刊题录与文摘--期刊详细文摘内容2009年早期孕期雄激素导致成年雌性恒河猴卵巢储备减少。哼哼责备。24：3188-3195。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To determine fetal, neonatal and adult markers reflecting mechanism of fetal programming of polycystic ovary syndrome (PCOS). This project continues to determine fetal and neonatal consequences of exposing female rhesus monkey fetuses to androgen excess during early gestation. Current results indicate that a hyperglycemic pregnancy induced by the androgen excess given to pregnant rhesus mothers may contribute to altered morphology of pancreatic islets in exposed female infants that may explain functional alterations in insulin-mediated regulation of glucose. This work provides additional direct evidence for fetal programming of metabolic defects in this nonhuman primate model of PCOS. This research used WNPRC Assay Services, Pathology Services and Animal Services. PUBLICATIONS: Abbott DH, Dumesic DA. 2009. Adult polycystic ovary. Highlights 17:13-18. Abbott DH, Tarantal AF, Dumesic DA. 2009 Fetal, infant, adolescent and adult phenotypes of polycystic ovary syndrome in prenatally androgenized female rhesus monkeys. Am J Primatol. 71:776-784. Dumesic DA, Patankar M, Barnett DK, Lesnick TG, Hutcherson BA, Abbott DH. 2009 Early prenatal androgenization results in diminished ovarian reserve in adult female rhesus monkeys. Hum Reprod. 24:3188-3195.