New Targets for Reproductive Control of Mosquito Vectors

描述（由申请方提供）：苔藓病媒生殖控制的新靶标。在这个项目中，我们将研究登革热和基孔肯雅病毒的两种主要疾病媒介：黄热病蚊子（埃及伊蚊）和亚洲虎蚊（白纹伊蚊）的雄性精液蛋白（SFPs）。登革热和基孔肯雅热在全球的发病率都在增加，迫切需要为这两个物种开发新的有效的病媒控制策略。在这项研究中，我们将进行两个具体的目标，以确定和功能特性的SFPs，第一次，在AE。aegypti和Ae.白纹伊蚊我们的目标是直接确定新的蚊子SFP目标，这些目标可以作为一种新的生殖控制手段，或者改变传播致命病原体的昆虫的吸血生理学，长期目标是减少或消除病毒传播给人类。

DESCRIPTION (provided by applicant): New Targets for Reproductive Control of Mosquito Vectors. In this project, we will investigate the male seminal fluid proteins (SFPs) of two major disease vectors of dengue and Chikungunya viruses: the yellow fever mosquito (Aedes aegypti) and the Asian tiger mosquito (Aedes albopictus). Both dengue and Chikungunya are increasing in incidence globally and there is an immediate need to develop novel and effective vector control strategies for these two species. In this study we will conduct two specific aims to identify and functionally characterize SFPs, for the first time, in Ae. aegypti and Ae. albopictus. Our goal is to directly identify new mosquito SFP targets that could be manipulated as a novel means of reproductive control, or to modify the blood feeding physiology of insects that transmit deadly pathogens, with the long-term goal to reduce or eliminate virus transmission to people.