Comprehensive Cancer Center of Wake Forest COOP Research Base

描述（由申请人提供）：这是维克森林社区临床肿瘤学计划研究基地（WF研究基地）综合癌症的第三次竞争性更新申请，该研究基地最初于1999年获得资助。未来五年的具体目标包括：具体目标1：通过在生存期内预防和治疗症状来提高患者的生活质量，从而开展影响社区肿瘤学实践的癌症控制研究（即，从诊断到治疗结束和从治疗结束向前）在以下主题领域：植物/天然产品和其它综合方法;常规药理学试剂;行为干预;非干预研究（例如，相关科学和观察/纵向研究;以及癌症预防试验）。具体目标二：利用相关科学与WF研究基地癌症对照研究相结合，了解癌症及其治疗的症状和毒性发生的基本机制。具体目标3：制定和利用创新的、文化上量身定制的战略，以增加传统上代表性不足的种族/族裔少数群体在癌症控制研究中的参与。具体目标4：促进积极的合作，并提供培训的发展，进行，并为CCOP/MBCCOP专业人员，早期职业教师和学员的癌症控制临床试验的报告。目前的申请是WF研究基地12年历史上最具竞争力的更新申请。随着时间的推移，我们增加了研究，应计费用和附属社区和机构的数量。我们的四个开放和四个即将开放的研究和20个发展中的概念的多样性，深度和广度是我们提供的独特和多样化的研究菜单的证据，以及我们为我们的参与CCOPs，MBCCOPs和预防成员填补的重要利基。

DESCRIPTION (provided by applicant): This is the third competing renewal application for the Comprehensive Cancer of Wake Forest Community Clinical Oncology Program Research Base (WF Research Base), which was initially funded in 1999. Specific Aims for the next five years include the following: Specific Aim 1: To conduct cancer control studies that impact community oncology practice by enhancing patients' quality of life through prevention and treatment of symptoms across the survivorship lifespan (i.e., from diagnosis to the end of therapy and from the end of therapy forward) in the following thematic areas: botanical/natural products and other integrative approaches; conventional pharmacologic agents; behavioral interventions; non-intervention studies (e.g., correlative science and observational/longitudinal studies; and cancer prevention trials). Specific Aim 2: To use correlative science in conjunction with WF Research Base cancer control studies to understand the basic mechanisms by which symptoms and toxicities of cancer and its treatments occur. Specific Aim 3: To develop and utilize innovative, culturally-tailored strategies to increase the participation of racial/ethnic minorities traditionaly underrepresented in cancer control studies. Specific Aim 4: To foster active collaboration and offer training in the development, conduct, and reporting of cancer control clinical trials for CCOP/MBCCOP professionals, early career faculty, and trainees. The current application is the strongest competing renewal application for the WF Research Base in our 12 year history. Over time, we have increased the number of studies, accruals, and affiliated communities and institutions. The diversity, depth and breadth of our four open and four soon-to-open studies and 20 developing concepts is evidence of the unique and diverse menu of studies we provide, and the important niche we fill for our participating CCOPs, MBCCOPs and Prevention Members.