Cohort study of Lausanne (COLAUS) on cardiovascular diseases and depression

这组数据的收集工作现已完成，数据分析工作正在进行中。国家精神卫生研究所(NIMH)对情感谱系障碍的家庭研究包括许多精神和心血管表型的可比指标，可以分析这些指标来为COLAUS制定假说，反之亦然。这项研究结果的第一份报告最近已提交出版(Glaus J.，等人，2011年)。 公共卫生影响： 心血管疾病及其公认的危险因素和精神障碍在所有慢性非传染性人类疾病中对公共健康的影响最大1。此外，世界卫生组织(世卫组织)最近对未来人口健康的预测得出结论，到2030年，单相抑郁障碍和缺血性心脏病将成为造成全球疾病负担的三大原因之一。鉴于CVD/CVRF和精神障碍对公共健康的重大影响，研究它们之间的联系的机制具有很高的临床和科学意义。 未来计划： 该项目的下一阶段包括对洛桑遗址的生物标志物和临床数据进行分析。然后，我们计划将NIMH家族研究的家庭研究数据和常见生物标记物与COLAUS研究的数据进行整合，以增强分析能力并交叉复制这些发现。然后，研究结果将被用于指导未来跟踪和扩展研究样本的计划。

The collection of data from this cohort has now been completed and analyses of the data are now underway. The National Institute of Mental Health (NIMH) family study of affective spectrum disorder has included numerous comparable measures of psychiatric and cardiovascular phenotypes that can be analyzed to develop hypotheses for COLAUS and conversely. The first report of the findings from this study has recently been submitted for publication (Glaus J., et al 2011). Public Health Impact: Cardiovascular diseases, their well established risk factors and mental disorders have the greatest public health impact of all chronic non-infectious human diseases 1. Moreover, a recent World Health Organization (WHO) projection of future population health concluded that by 2030, unipolar depressive disorders and ischemic heart disease (IHD) will be among the three leading causes of disease burden worldwide. Given the major public health impact of both CVD/CVRF and mental disorders, the study of the mechanisms underlying their associations is of high clinical and scientific relevance. Future Plans: The next phase of this project involves analysis of the biomarker and clinical data in the Lausanne site. We then plan to integrate the family study data and common biomarkers from the NIMH Family Study with those of the COLAUS study to enhance analytic power and to cross-replicate the findings. The results will then be used to guide plans for future follow-up and extension of the study samples.